Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Environ Int. 2019 Jul;128:254-260. doi: 10.1016/j.envint.2019.04.064. Epub 2019 May 3.
Telomere length (TL) is considered as a surrogate of biological aging and has been related to aging-related diseases. The initial setting of newborn TL has important implications for telomere dynamics in adulthood, and is affected by the intrauterine environment. However, the effects of prenatal air pollution exposure on the initial setting of newborn TL are poor understood.
We aimed to explore the trimester-specific relationships between maternal air pollution exposure and newborn TL.
Between November 2013 and March 2015, a total of 762 mother-newborn pairs were recruited in a birth cohort study in Wuhan, China. Relative cord blood TL was assessed using quantitative real-time polymerase chain reaction. Maternal exposures to PM, PM, SO, CO, and NO, were determined using spatial-temporal land use regression models. Multiple informant models were applied to explore the trimester-specific associations of maternal air pollution exposure with cord blood TL.
In single-pollutant models, a 10 μg/m increase in PM, PM, SO, and a 100 μg/m increase in CO during the third trimester were related to 3.71% (95% confidence interval [CI]: -6.06%, -1.30%), 3.24% (95% CI: -5.29%, -1.14%), 11.07% (95% CI: -18.86%, -2.53%), and 3.67% (95% CI: -6.27%, -1.00%) shorter cord blood TL, respectively. The inverse relationships between exposures to PM, PM, SO, and CO during the third trimester and cord blood TL were more evident in male infants. In multi-pollutant models, exposures to PM and PM during the third trimester were both related to shorter cord blood TL, but not SO and CO.
This study suggested that maternal exposures to PM, PM, CO, and SO during the third trimester were related to shorter newborn TL, which highlights the importance of improving air quality in favor of subsequent health in later life of newborns.
端粒长度（TL）被认为是生物衰老的替代物，与衰老相关疾病有关。新生儿 TL 的初始设定对成年后端粒动力学具有重要意义，并受宫内环境的影响。然而，产前空气污染暴露对新生儿 TL 初始设定的影响知之甚少。
我们旨在探讨母体空气污染暴露与新生儿 TL 之间的特定孕期关系。
2013 年 11 月至 2015 年 3 月，在中国武汉的一项出生队列研究中招募了总共 762 对母婴。采用实时定量聚合酶链反应测定脐带血 TL 相对值。使用时空土地利用回归模型确定 PM、PM、SO、CO 和 NO 的母体暴露情况。采用多信息模型探讨母体空气污染暴露与脐带血 TL 在特定孕期的关系。
在单污染物模型中，第三孕期 PM、PM、SO 每增加 10μg/m 和 CO 每增加 100μg/m，与脐带血 TL 分别缩短 3.71%（95%置信区间：-6.06%，-1.30%）、3.24%（95%置信区间：-5.29%，-1.14%）、11.07%（95%置信区间：-18.86%，-2.53%）和 3.67%（95%置信区间：-6.27%，-1.00%）有关。第三孕期 PM、PM、SO 和 CO 暴露与脐带血 TL 之间的负相关关系在男婴中更为明显。在多污染物模型中，第三孕期 PM 和 PM 暴露均与脐带血 TL 缩短有关，但 SO 和 CO 则不然。
本研究表明，第三孕期母体 PM、PM、CO 和 SO 暴露与新生儿 TL 缩短有关，这强调了改善空气质量以有利于新生儿后期健康的重要性。
