Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ion Beam Applications, Advanced Technology Group, Louvain-la-Neuve, Belgium.
Phys Med Biol. 2020 Dec 18;65(23):23NT01. doi: 10.1088/1361-6560/abc5c8.
The treatment of moving targets with pencil beam scanned proton therapy (PBS-PT) may rely on rescanning strategies to smooth out motion induced dosimetric disturbances. PBS-PT machines, such as Proteus®Plus (PPlus) and Proteus®One (POne), deliver a continuous or a pulsed beam, respectively. In PPlus, scaled (or no) rescanning can be applied, while POne implies intrinsic 'rescanning' due to its pulsed delivery. We investigated the efficacy of these PBS-PT delivery types for the treatment of lung tumours. In general, clinically acceptable plans were achieved, and PPlus and POne showed similar effectiveness.
笔形束扫描质子治疗（PBS-PT）治疗移动靶区可能依赖于重扫描策略来平滑运动引起的剂量学干扰。PBS-PT 设备，如 Proteus®Plus（PPlus）和 Proteus®One（POne），分别提供连续或脉冲束。在 PPlus 中，可以应用缩放（或不应用）重扫描，而由于其脉冲输送，POne 意味着内在的“重扫描”。我们研究了这些 PBS-PT 输送类型治疗肺部肿瘤的效果。通常，可以实现临床可接受的计划，并且 PPlus 和 POne 显示出相似的效果。
