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[中国九家医院孕产妇静脉血栓栓塞相关因素调查]

[Survey of related factors of maternal venous thromboembolism in nine hospitals of China].

作者信息

Wang Z L, Geng H Z, Zhao X L, Zhu Q Y, Lin J H, Zou L, Mi Y, Hu Y L, Fan S R, Chen X, Liu Z, Yang H X

机构信息

Department of Obstetrics,the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

Department of Obstetrics and Gynecology,the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 2020 Oct 25;55(10):667-672. doi: 10.3760/cma.j.cn112141-20200414-00326.

Abstract

To investigate and analyze disease status and risk factors of venous thromboembolism (VTE) during pregnancy and puerperium in our country. Clinical datas were collected from 575 patients diagnosed with VTE during pregnancy and puerperium and hospitalized in nine medical institutions in our country from January 1, 2015 to November 30, 2019, and retrospectively analyzed it's disease status and risk factors. (1) The proportion of VTE in pregnancy and puerperium was 50.6% (291/575) and 49.4% (284/575), respectively. Four patients died, the mortality rate was 0.7% (4/575). The cause of death was pulmonary embolism. (2) The location of VTE during pregnancy and puerperium was mainly in the lower limb vascular (76.2%, 438/575), followed by pulmonary vessels (7.1%, 41/575). (3) In the risk factors of VTE, cesarean section accounted for 32.3% (186/575), maternal advance age accounted for 27.7% (159/575), braking or hospitalization during pregnancy accounted for 13.6% (78/575), other risk factors accounted for more than 5% were previous VTE, obesity, preterm birth, assistant reproductive technology conception and so on, pre-eclampsia and multiple pregnancy accounted for 4.9% (28/575) respectively. In addition, some patients with VTE did not have any of the above risk factors, and the incidence rate was as high as 23.1% (133/575). The occurrence of VTE during pregnancy and puerperium is related to multiple risk factors, and could lead to matemal death, It is very necessary to screen VTE risk factors for all pregnant women, to make corresponding prevention and control measures.

摘要

调查分析我国妊娠期及产褥期静脉血栓栓塞症(VTE)的疾病状况及危险因素。收集2015年1月1日至2019年11月30日期间在我国9家医疗机构住院的575例妊娠期及产褥期诊断为VTE的患者的临床资料,并对其疾病状况及危险因素进行回顾性分析。(1)妊娠期及产褥期VTE的比例分别为50.6%(291/575)和49.4%(284/575)。4例患者死亡,死亡率为0.7%(4/575)。死亡原因是肺栓塞。(2)妊娠期及产褥期VTE的部位主要在下肢血管(76.2%,438/575),其次是肺血管(7.1%,41/575)。(3)在VTE的危险因素中,剖宫产占32.3%(186/575),产妇高龄占27.7%(159/575),孕期制动或住院占13.6%(78/575),其他危险因素占比超过5%的有既往VTE、肥胖、早产、辅助生殖技术受孕等,子痫前期和多胎妊娠分别占4.9%(28/575)。此外,部分VTE患者无上述任何危险因素,发生率高达23.1%(133/575)。妊娠期及产褥期VTE的发生与多种危险因素有关,可导致孕产妇死亡,对所有孕妇进行VTE危险因素筛查并采取相应的防控措施非常必要。

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