Siddharthan K S, Shet Varna, Agrawal Anushri, Reddy Jagdeesh Kumar
Head-Cornea Services, Sankara Eye Hospital, Coimbatore, India.
DNB Student, Sankara Eye Hospital, Coimbatore, India.
Indian J Ophthalmol. 2020 Nov;68(11):2408-2414. doi: 10.4103/ijo.IJO_2364_19.
The purpose of this study is to evaluate 2-year clinical outcome after Descemet membrane endothelial keratoplasty (DMEK) in a variety of endothelial dysfunctions using a standardized protocol.
: From a group of 230 eyes which underwent DMEK for Fuchs' endothelial corneal dystrophy (FECD), aphakic and pseudophakic bullous keratopathy, failed full thickness corneal transplants, ICE syndrome, failed DSEK, and TASS the clinical outcomes [best spectacle-corrected visual acuity (BSCVA), central endothelial cell density (ECD)] were evaluated before, and at 6, 12, and 24 months and the success rate, failure rate and postoperative complications were also analyzed.
Out of 230 eyes, 144 eyes (70%) had BSCVA 6/9 or better 2 years postoperatively. Mean donor ECD was 2692.23 (range, 2300-3436) cells/mm preoperatively, which was reduced to 1433.64 (range, 619.0-2272.0) cells/mm 2 years after DMEK surgery, indicating a mean reduction of 1258 cells/mm (46%) in ECD.
DMEK is a highly successful surgical procedure when following a standard protocol for treating diseases of the corneal endothelium providing a near perfect anatomic restoration and a high degree of visual rehabilitation.
本研究旨在使用标准化方案评估在各种内皮功能障碍中进行Descemet膜内皮角膜移植术（DMEK）后的2年临床结果。
在一组230只接受DMEK手术治疗Fuchs内皮角膜营养不良（FECD）、无晶状体和人工晶状体大泡性角膜病变、全层角膜移植失败、ICE综合征、DSEK失败和TASS的眼中，评估术前、术后6个月、12个月和24个月的临床结果[最佳矫正视力（BSCVA）、中央内皮细胞密度（ECD）]，并分析成功率、失败率和术后并发症。
230只眼中，144只眼（70%）术后2年的BSCVA为6/9或更好。术前供体ECD的平均值为2692.23（范围2300 - 3436）个细胞/mm，DMEK手术后2年降至1433.64（范围619.0 - 2272.0）个细胞/mm，表明ECD平均减少1258个细胞/mm（46%）。
当遵循治疗角膜内皮疾病的标准方案时，DMEK是一种非常成功的手术方法，可提供近乎完美的解剖修复和高度的视力恢复。
