Kuo Ting-Ya, Wu Chung-Ze, Lu Chieh-Hua, Lin Jiunn-Diann, Liang Yao-Jen, Hsieh Chang-Hsun, Pei Dee, Chen Yen-Lin
Department of Internal Medicine, Fu-Jen Catholic Hospital, Fu Jen Catholic University, School of Medicine, New Taipei City, Taiwan, ROC.
Division of Endocrinology, Department of Internal Medicine, Shuang Ho Hospital; Division of Endocrinology and Metabolism, School of Medicine, College of Medicine, Taipei Medical University.
Medicine (Baltimore). 2020 Oct 23;99(43):e22215. doi: 10.1097/MD.0000000000022215.
The Increasing prevalence of type 2 diabetes mellitus (T2DM) has been observed in younger adults. Insulin resistance [IR], decreased first-, second-phase insulin secretion, and glucose effectiveness (GE) (IR, first phase insulin secretion [FPIS], second phase insulin secretion [SPIS], and GE), denoted as diabetes factors (DF), are core for developing T2DM. A body of evidence has shown that inflammation contributes to the development of diabetes. In the present study, our goals were first, evaluate the relationships between white blood cell (WBC) count and, second, examine the relative tightness between the 4 DFs to WBC count. Thus, the pathophysiology of T2DM in Chinese young men could be more understood.21112 non-obese males between 18 to 27 years old were recruited (mean age: 24.3 ± 0.017), including 1745 subjects with metabolic syndrome. DFs were calculated by the published equations by our groups as follows:The association between DFs and WBC count was analyzed using a simple correlation. The r-values of the simple correlation are regarded as the tightness of the relationships.Higher WBC, FPIS, SPIS, IR, age, BMI, blood pressure, FPG, TG, Cholesterol, low-density lipoprotein cholesterol and lower HDL-C and GE were observed in subjects with metabolic syndrome. A similar trend was seen across the quartiles of WBC levels. Among the 4 DFs, GE has the highest r-value (r = -0.093, P < .001), followed by IR (r = 0.067, P < .001), SPIS (r = 0.029, P < .001) and FPIS (r = 0.027, P < .001).Elevated WBC count is significantly associated with all the 4 DFs and the relative order of the tightness, from the highest to the lowest, are GE, IR, SPIS, and FPIS in Chinese young men.
在年轻成年人中，2型糖尿病（T2DM）的患病率呈上升趋势。胰岛素抵抗（IR）、第一相和第二相胰岛素分泌减少以及葡萄糖有效性（GE）（IR、第一相胰岛素分泌[FPIS]、第二相胰岛素分泌[SPIS]和GE），被称为糖尿病因素（DF），是T2DM发病的核心因素。大量证据表明，炎症会促进糖尿病的发展。在本研究中，我们的目标一是评估白细胞（WBC）计数之间的关系，二是研究4种糖尿病因素与WBC计数之间的相对紧密程度。从而能更好地理解中国年轻男性T2DM的病理生理学。招募了21112名18至27岁的非肥胖男性（平均年龄：24.3±0.017），其中包括1745名患有代谢综合征的受试者。糖尿病因素由我们团队发表的公式计算如下：使用简单相关性分析糖尿病因素与WBC计数之间的关联。简单相关性的r值被视为关系的紧密程度。患有代谢综合征的受试者白细胞、第一相胰岛素分泌、第二相胰岛素分泌、胰岛素抵抗、年龄、体重指数、血压、空腹血糖、甘油三酯、胆固醇、低密度脂蛋白胆固醇较高，高密度脂蛋白胆固醇和葡萄糖有效性较低。在白细胞水平的四分位数中也观察到类似趋势。在4种糖尿病因素中，葡萄糖有效性的r值最高（r = -0.093，P <.001），其次是胰岛素抵抗（r = 0.067，P <.001）、第二相胰岛素分泌（r = 0.029，P <.001）和第一相胰岛素分泌（r = 0.027，P <.001）。白细胞计数升高与所有4种糖尿病因素均显著相关，在中国年轻男性中，紧密程度从高到低的相对顺序为葡萄糖有效性、胰岛素抵抗、第二相胰岛素分泌和第一相胰岛素分泌。
