Jin Hongyu, Zhang Man, Zhou Hui, Zhu Shiyu, Hu Chenggong
Department of Liver Surgery, Liver Transplantation Center.
West China School of Medicine.
Medicine (Baltimore). 2020 Oct 23;99(43):e22760. doi: 10.1097/MD.0000000000022760.
Several preoperative blood and biochemical parameters are associated with postoperative survival in many kinds of tumors. The aim of this study is to study the predictive value of several routine preoperative blood and biochemical parameters on the prognosis patients with rhabdomyosarcoma (RMS).We retrospectively recruited 55 patients diagnosed with RMS and had surgery at West China Hospital, Sichuan University between January 2010 and December 2018. Baseline characteristics of the patients, tumor features, surgery details, and values of several examinations were extracted. A long-term follow-up was conducted by phone call. A novel statistical analysis was subsequently carried out to look for the relationship of preoperative parameters and patients' prognosis.The ROC analysis showed an area under curve (AUC) of 0.608, 0.620, 0.626, 0.591, and 0.518 for neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), lactic dehydrogenase (LDH), and alkaline phosphatase (ALP) respectively, and the cut-off value of 2.843, 162.961, and 0.239 for NLR, PLR, and MLR respectively. The survival analysis showed that certain blood and biochemical parameters could cause differences in overall survival (OS) (P = .005 for NLR, P = .005 for PLR, and P = .007 for MLR) and progression free survival (PFS) (P = .029 for NLR, P = .008 for PLR, and P = .013 for MLR).Several preoperative blood and biochemical parameters are novel prognostic factors in RMS patients. Specifically, a higher NLR, PLR, and MLR value will predict a statistically shorter OS and PFS.In the future, surgeons should care more about NLR, PLR, and MLR values and several other parameters in patients' preoperative normal blood and biochemical tests to predict the postoperative conditions.
多种术前血液和生化参数与多种肿瘤的术后生存率相关。本研究旨在探讨几种常规术前血液和生化参数对横纹肌肉瘤（RMS）患者预后的预测价值。我们回顾性招募了2010年1月至2018年12月期间在四川大学华西医院被诊断为RMS并接受手术的55例患者。提取了患者的基线特征、肿瘤特征、手术细节以及多项检查的值。通过电话进行长期随访。随后进行了一项新颖的统计分析，以寻找术前参数与患者预后的关系。ROC分析显示，中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）、乳酸脱氢酶（LDH）和碱性磷酸酶（ALP）的曲线下面积（AUC）分别为0.608、0.620、0.626、0.591和0.518，NLR、PLR和MLR的截断值分别为2.843、162.961和0.239。生存分析表明，某些血液和生化参数可导致总生存期（OS）出现差异（NLR的P = 0.005，PLR的P = 0.005，MLR的P = 0.007）以及无进展生存期（PFS）出现差异（NLR的P = 0.029，PLR的P = 0.008，MLR的P = 0.013）。几种术前血液和生化参数是RMS患者新的预后因素。具体而言，较高的NLR、PLR和MLR值预示着在统计学上OS和PFS更短。未来，外科医生应更加关注患者术前血常规和生化检查中的NLR、PLR和MLR值以及其他一些参数，以预测术后情况。
