5-甲基四氢高叶酸
5-Methyltetrahydrohomofolate.
作者信息
O'Dwyer P J, Wagner B H, Hoth D F, Leyland-Jones B
机构信息
Investigational Drug Branch, National Cancer Institute, Philadelphia.
出版信息
Invest New Drugs. 1987;5(3):215-8. doi: 10.1007/BF00175290.
PMID:3312079
Abstract
5-methyltetrahydrohomofolate was developed in the 1970's as an antifolate with the potential to overcome methotrexate resistance. This review summarizes the preclinical and clinical data which have accumulated to date. It is concluded that more recent, better characterized antifolates offer greater potential in achieving the goals for which this drug was introduced.
摘要
5-甲基四氢高叶酸在20世纪70年代被开发出来，作为一种抗叶酸药物，有可能克服甲氨蝶呤耐药性。本综述总结了迄今为止积累的临床前和临床数据。结论是，更新的、特征更明确的抗叶酸药物在实现引入该药物的目标方面具有更大的潜力。
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