Otsuka F L, Welch M J
Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Int J Rad Appl Instrum B. 1987;14(3):243-9. doi: 10.1016/0883-2897(87)90048-1.
The use of radiolabeled monoclonal antibodies as a diagnostic tool in nuclear medicine has grown rapidly over the past several years. Early studies utilized antibodies labeled with radionuclides of iodine (i.e. 125I and 131I) although these radionuclides are not ideal for use in tumor imaging. Recent advances and the development of new chemical methods has made it possible to label antibodies with other radionuclides (i.e. 77Br, 111In and 99mTc). The advantages and disadvantages associated with all of the different radionuclides and labeling methods will be discussed.
在过去几年中，放射性标记单克隆抗体作为核医学中的一种诊断工具的应用迅速增长。早期研究使用用碘的放射性核素（即125I和131I）标记的抗体，尽管这些放射性核素并不适合用于肿瘤成像。最近的进展和新化学方法的开发使得用其他放射性核素（即77Br、111In和99mTc）标记抗体成为可能。将讨论与所有不同放射性核素和标记方法相关的优缺点。
