Department of Obstetrics and Gynecology, Lehigh Valley Health Network, 707 Hamilton Blvd, 8th Floor, Allentown, PA 18101, USA.
Department of Obstetrics and Gynecology, Lehigh Valley Health Network, 707 Hamilton Blvd, 8th Floor, Allentown, PA 18101, USA.
Obstet Gynecol Clin North Am. 2020 Dec;47(4):545-567. doi: 10.1016/j.ogc.2020.08.002.
A short cervix in the second trimester is a significant risk factor for spontaneous preterm birth, preterm prelabor rupture of membranes, and subsequent adverse perinatal outcome. The pathophysiology is complex and multifactorial with inflammatory and/or infectious processes often involved. Biomarkers have been developed in an effort to predict preterm birth with varying degrees of success. The treatment options of cerclage, progesterone, pessary, and combination therapy are reviewed. Evidence-based protocols are summarized for singleton and multiple gestation.
在妊娠中期，宫颈过短是自发性早产、胎膜早破早产和随后不良围产期结局的重要危险因素。其病理生理学较为复杂，涉及多种因素，包括炎症和/或感染过程。目前已经开发了生物标志物来预测早产，其成功率也有所不同。本文对宫颈环扎术、孕激素、子宫托以及联合治疗等治疗方法进行了综述。同时，还总结了单胎和多胎妊娠的基于证据的方案。
