Lippman M E, Dickson R B, Gelmann E P, Rosen N, Knabbe C, Bates S, Bronzert D, Huff K, Kasid A
Medical Breast Cancer Section, National Cancer Institute, Bethesda, Maryland 20892.
J Cell Biochem. 1987 Sep;35(1):1-16. doi: 10.1002/jcb.240350102.
We describe studies on human breast cancer in which it is shown that specific growth factors (IGF-I, TGF alpha, PDGF) are secreted by human breast cancer cells and likely to be involved in tumor growth and progression. These activities are regulated by estradiol in hormone-dependent breast cancer and secreted constitutively by hormone-independent cells. These growth factor activities can induce the growth of hormone-dependent cells in vivo in athymic nude mice. Hormone-dependent breast cancer cells also secrete TGF beta, a growth-inhibitory substance, when treated with antiestrogens. TGF beta functions as a negative autocrine growth regulator and is responsible for some of the growth-inhibitory effects of antiestrogens.
我们描述了对人类乳腺癌的研究，研究表明特定生长因子（胰岛素样生长因子-I、转化生长因子α、血小板衍生生长因子）由人类乳腺癌细胞分泌，且可能参与肿瘤生长和进展。在激素依赖性乳腺癌中，这些活性受雌二醇调节，而在激素非依赖性细胞中则持续分泌。这些生长因子活性可在无胸腺裸鼠体内诱导激素依赖性细胞生长。当用抗雌激素处理时，激素依赖性乳腺癌细胞也会分泌一种生长抑制物质——转化生长因子β。转化生长因子β作为一种负性自分泌生长调节因子，介导了抗雌激素的一些生长抑制作用。
