Nakayama Taiga, Nagai Yoshio, Yasunaka Yuka, Uraguchi Takeo, Wada Yukihisa, Sone Masakatsu, Tanaka Yasushi
Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Department of Internal Medicine, Sakawa Municipal Kohoku Hospital, Takaoka-Gun, Kochi, Japan.
J Nutr Metab. 2020 Oct 14;2020:8847781. doi: 10.1155/2020/8847781. eCollection 2020.
We have previously demonstrated that eating glutinous brown rice (GBR) for 1 day or 8 weeks was well accepted and improved glycemic control in patients with type 2 diabetes. The present study evaluated whether eating GBR could also improve glucose metabolism in subjects without diabetes. A prospective 6-week, single-center, randomized, open-label, parallel-group study was carried out in subjects receiving annual medical checkup at our hospital. A total of 42 subjects were randomly assigned to continue their regular diet (RD group) or to switch GBR twice a day (GBR group). The primary outcome was the change in the serum concentration of 1,5-anhydroglucitol (1,5-AG) from baseline after the 6-week dietary intervention. One subject was excluded from the analysis because of a traffic accident. After 6 weeks, the serum 1,5-AG was significantly increased in the GBR group and the mean treatment difference (GBR group - RD group) was 1.1 g/mL (95% CI: 0.6 to 1.6, =0.022). Body mass index decreased significantly in both groups, with no significant difference between them (=0.210). There were no changes in fasting plasma glucose, fasting insulin, or eating behavior. Intake of GBR for 6 weeks significantly increased serum 1,5-AG in Japanese subjects without diabetes. The increase of 1,5-AG may have been due to the alleviation of postprandial hyperglycemia, which could be effective for the primary prevention of diabetes.
我们之前已经证明，2型糖尿病患者食用1天或8周的糙糯米（GBR）后耐受性良好，且血糖控制得到改善。本研究评估了食用GBR是否也能改善非糖尿病受试者的葡萄糖代谢。我们在我院接受年度体检的受试者中开展了一项为期6周的前瞻性、单中心、随机、开放标签、平行组研究。共有42名受试者被随机分配，继续其常规饮食（RD组）或改为每天食用两次GBR（GBR组）。主要结局是6周饮食干预后血清1,5-脱水葡萄糖醇（1,5-AG）浓度相对于基线的变化。一名受试者因交通事故被排除在分析之外。6周后，GBR组的血清1,5-AG显著升高，平均治疗差异（GBR组−RD组）为1.1 g/mL（95%CI：0.6至1.6，P=0.022）。两组的体重指数均显著下降，两组之间无显著差异（P=0.210）。空腹血糖、空腹胰岛素或饮食行为均无变化。在非糖尿病日本受试者中，食用6周GBR可显著提高血清1,5-AG。1,5-AG的升高可能是由于餐后高血糖的缓解，这可能对糖尿病的一级预防有效。
