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导丝与无导丝在输尿管支架取出中的疗效和安全性:哪种更好?

The Efficacy and Safety of Ureteric Stent Removal with Strings versus No Strings: Which Is Better?

机构信息

Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.

Department of Urology, China-Japan Friendship Hospital, Beijing, China.

出版信息

Biomed Res Int. 2020 Oct 15;2020:4081409. doi: 10.1155/2020/4081409. eCollection 2020.

Abstract

OBJECTIVE

To evaluate the current evidence on the effectiveness and safety of ureteric stent removal using strings compared to conventional methods.

MATERIALS AND METHODS

The electronic databases PubMed, Embase, China National Knowledge Infrastructure (CNKI), and the Cochrane Library were systematically searched up to March 2020. Two reviewers searched the literature, independently extracted the data, and evaluated the quality of the studies according to the inclusion and exclusion criteria. The data analysis was performed with the software program Review Manager 5.3.

RESULTS

Eleven studies with a total of 1809 patients were included in the analysis based on the inclusion criteria. Our meta-analysis showed that visual analogue scale (VAS) scores were significantly lower in the string group than in the conventional group (weighted mean difference (WMD) -2.63; 95% confidence interval (CI) -3.68, -1.58; < 0.00001). In terms of stent dwell time, the string group had an advantage (WMD -9.53; 95% CI -14.20, -4.86; < 0.0001). In addition, no significant differences in the occurrence of urinary tract infection (UTI) (odds ratio (OR) 1.03; 95% CI 0.62, 1.72; = 0.92), emergency room visits (OR 0.99; 95% CI 0.59, 1.67; = 0.97), or other complications ( > 0.05) were observed between the two groups.

CONCLUSION

Our findings suggest that an extraction string is an effective and safe method for the removal of ureteric stents. This method gives patients the benefits of reduced pain and shortened stent dwell time without increasing the risk of UTI. Nevertheless, these findings should be further confirmed through large-volume, well-designed prospective randomized controlled trials (RCTs).

摘要

目的

评估与传统方法相比,使用导丝取出输尿管支架的有效性和安全性的现有证据。

材料与方法

系统检索了电子数据库 PubMed、Embase、中国知网(CNKI)和 Cochrane 图书馆,检索时间截至 2020 年 3 月。两位审查员根据纳入和排除标准搜索文献、独立提取数据并评估研究质量。使用软件 Review Manager 5.3 进行数据分析。

结果

根据纳入标准,共有 11 项研究,总计 1809 例患者纳入分析。我们的荟萃分析显示,与传统组相比,导丝组的视觉模拟评分(VAS)显著降低(加权均数差(WMD)-2.63;95%置信区间(CI)-3.68,-1.58;<0.00001)。在支架留置时间方面,导丝组具有优势(WMD-9.53;95%CI-14.20,-4.86;<0.0001)。此外,两组间尿路感染(UTI)的发生率(比值比(OR)1.03;95%CI 0.62,1.72;=0.92)、急诊就诊率(OR 0.99;95%CI 0.59,1.67;=0.97)或其他并发症(>0.05)无显著差异。

结论

我们的研究结果表明,使用提取导丝取出输尿管支架是一种有效且安全的方法。这种方法可减轻患者疼痛,缩短支架留置时间,而不会增加 UTI 的风险。然而,这些发现需要通过大样本、精心设计的前瞻性随机对照试验(RCT)进一步证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede3/7584935/37923b382d8e/BMRI2020-4081409.001.jpg

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