Division of Pediatric Urology, Children's Medical Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Division of Pediatric Urology, Children's Medical Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Pediatr Urol. 2023 Oct;19(5):515.e1-515.e5. doi: 10.1016/j.jpurol.2023.05.017. Epub 2023 Jun 2.
Ureteral stents facilitate recovery and avoid external drains in pediatric ureteral reconstruction. Extraction strings avoid the need for a secondary cystoscopy and anesthetic. Due to concerns regarding febrile UTIs in children with extraction strings, we retrospectively assessed the relative risk of UTI in children with extraction strings.
Our hypothesis was that stents with extraction strings do not increase the risk of UTI after pediatric ureteral reconstruction.
Records of all children undergoing pyeloplasty and ureteroureterostomy (UU) from 2014 to 2021 were reviewed. The incidences of UTI, fever, and hospitalization were recorded.
245 patients mean age 6.4 years (163M:82F) underwent pyeloplasty (n = 221) or UU (n = 24). 42% (n = 103) received prophylaxis. Of these, 15% developed UTI versus 5% of those not receiving prophylaxis (p < 0.05). 42 females had prior history of UTI, compared to 20 males (p < 0.05). 49 patients had an extraction string. Stents with extraction strings were removed on average 0.6 months post-op while others underwent cystoscopic removal on average 1.26 months post-op (p < 0.05). 9 (18.4%) required hospitalization for febrile UTI while the stent with extraction string was in place, while only 13 (6.6%) of those without extraction string did (p < 0.02). Of the 9 children with a febrile UTI in the extraction string group, 6 had history of prior UTI (46.1%), compared to only 3 (8.3%) without a prior UTI (p < 0.05). With no prior UTI, there was no difference in UTI risk between those with (3, 8.3%) and without (8, 6.4%) extraction string (p = 0.71). Females with prior UTI and extraction string were more likely to develop UTI than those with prior UTI and no extraction string (p = 0.01). There were not enough males with history of UTI to analyze alone. There were 5 (10%) stent dislodgements in the extraction string group, 2 required further intervention with cystoscopy or percutaneous drainage.
Extraction strings provide the assurance of drainage while avoiding the need for a second general anesthetic procedure. There is not an increased risk of UTI with extraction string in those without prior history of UTI, but we no longer routinely leave extraction strings if there is history of UTI.
Children, particularly females, with prior history of UTI have a significantly increased risk of febrile UTIs associated with the use of extraction strings. Prophylaxis does not seem to reduce this risk. Patients with no prior UTI had no higher risk of UTI with extraction string use for pyeloplasty or UU.
输尿管支架有助于恢复并避免小儿输尿管重建后的外部引流。提取线避免了二次膀胱镜检查和麻醉的需要。由于担心有提取线的儿童发生发热性尿路感染,我们回顾性评估了有提取线的儿童发生尿路感染的相对风险。
我们的假设是,在小儿输尿管重建后,带有提取线的支架不会增加尿路感染的风险。
回顾了 2014 年至 2021 年间所有接受肾盂成形术和输尿管-输尿管吻合术(UU)的儿童的记录。记录尿路感染、发热和住院的发生率。
245 名平均年龄为 6.4 岁(163 名男性:82 名女性)的儿童接受了肾盂成形术(n=221)或 UU(n=24)。42%(n=103)接受了预防治疗。其中,15%发生了尿路感染,而未接受预防治疗的感染率为 5%(p<0.05)。42 名女性有既往尿路感染史,而 20 名男性有(p<0.05)。49 名患者有提取线。带提取线的支架在术后平均 0.6 个月取出,而其他支架在术后平均 1.26 个月进行膀胱镜检查取出(p<0.05)。有 9 名(18.4%)因发热性尿路感染需要住院治疗,而在放置提取线的支架时,只有 13 名(6.6%)无提取线的患者需要住院治疗(p<0.02)。在提取线组中,有 9 名发热性尿路感染的儿童中,有 6 名(46.1%)有既往尿路感染史,而无提取线的 3 名(8.3%)没有(p<0.05)。在无既往尿路感染的情况下,带提取线和不带提取线的儿童发生尿路感染的风险无差异(带提取线的 3 名,8.3%;不带提取线的 8 名,6.4%)(p=0.71)。有既往尿路感染且有提取线的女性比有既往尿路感染且无提取线的女性更容易发生尿路感染(p=0.01)。没有足够的有尿路感染史的男性进行单独分析。提取线组有 5 名(10%)支架移位,2 名需要进一步进行膀胱镜检查或经皮引流。
提取线在提供引流的同时避免了再次全身麻醉的需要。对于无既往尿路感染史的患者,使用提取线并不会增加尿路感染的风险,但如果有尿路感染史,我们不再常规放置提取线。
有既往尿路感染史的儿童,尤其是女性,使用提取线后发生发热性尿路感染的风险显著增加。预防治疗似乎并不能降低这种风险。无既往尿路感染史的患者,使用提取线行肾盂成形术或 UU 时,尿路感染风险无增加。