Allen D H, Delohery J, Baker G
Department of Thoracic Medicine, Royal North Shore Hospital, Sydney, Australia.
J Allergy Clin Immunol. 1987 Oct;80(4):530-7. doi: 10.1016/0091-6749(87)90003-0.
Ingested chemicals, including aspirin and sulfites, are becoming increasingly recognized as provokers of acute severe asthma. In order to investigate the asthma-provoking potential of the widely used flavor enhancer, monosodium L-glutamate (MSG), we challenged 32 subjects with asthma, a number of whom gave histories of severe asthma after Chinese restaurant meals or similarly spiced meals. The subjects received an additive-free diet for 5 days before challenge and were challenged in hospital, after an overnight fast, with 500 mg capsules of MSG. They were challenged in a single-blind, placebo-controlled fashion with increasing doses of MSG from 0.5 gm to 5.0 gm. Thirteen subjects reacted. Seven subjects (group 1) developed asthma and symptoms of the Chinese restaurant syndrome 1 to 2 hours after ingestion of MSG. Six subjects (group 2) did not develop symptoms of Chinese restaurant syndrome, and their asthma developed 6 to 12 hours after ingestion of MSG. These challenge studies confirm that MSG can provoke asthma. The reaction to MSG is dose dependent and may be delayed up to 12 hours, making recognition difficult for both patient and physician.
摄入的化学物质，包括阿司匹林和亚硫酸盐，越来越被认为是急性重症哮喘的诱发因素。为了研究广泛使用的增味剂L-谷氨酸钠（味精）诱发哮喘的可能性，我们对32名哮喘患者进行了激发试验，其中一些患者有在中餐馆用餐或食用类似调味餐食后出现严重哮喘的病史。受试者在激发试验前5天食用无添加剂饮食，并在医院过夜禁食后，服用500毫克味精胶囊进行激发试验。他们以单盲、安慰剂对照的方式，使用从0.5克到5.0克递增剂量的味精进行激发试验。13名受试者出现反应。7名受试者（第1组）在摄入味精后1至2小时出现哮喘和中餐馆综合征症状。6名受试者（第2组）未出现中餐馆综合征症状，他们的哮喘在摄入味精后6至12小时发作。这些激发试验证实味精可诱发哮喘。对味精的反应呈剂量依赖性，且可能延迟长达12小时，这使得患者和医生都难以识别。
