Hurault de Ligny B, Mintz P, Ryckelynck J P, Herlicoviez M, Muller G, Lévy G
Service de Néphrologie, C.H.U. Clemenceau, Caen.
J Gynecol Obstet Biol Reprod (Paris). 1987;16(5):643-8.
The authors report three cases where captopril was used in pregnancy. This was shown to be more useful in cases of essential hypertension than in toxaemia. There was no bad side effect from the use of Captopril. It did not alter the fetal growth once the hypertension was well controlled. Using it together with other anti-hypertensives has to be thought out very carefully and it has to be used with great care. The state of the newborns at birth was satisfactory. Follow-up was without complications except for one case where was a persistent ductus. Whether captopril had any role to play in this is uncertain. Although these results are good, captopril should not be used as first choice treatment in hypertension.
作者报告了三例妊娠期间使用卡托普利的病例。结果表明，卡托普利在原发性高血压病例中比在子痫前期更有用。使用卡托普利未出现不良副作用。一旦高血压得到良好控制，它不会改变胎儿生长。与其他抗高血压药物联合使用时必须非常谨慎考虑，且必须谨慎使用。出生时新生儿状况良好。随访期间除一例持续性动脉导管未闭外无并发症。卡托普利在其中是否起作用尚不确定。尽管这些结果良好，但卡托普利不应作为高血压的首选治疗药物。
