Internal Medicine and Specialities Department, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
Internal Medicine Department, Yaoundé General Hospital, Yaoundé, Cameroon.
Echocardiography. 2021 Jan;38(1):25-30. doi: 10.1111/echo.14915. Epub 2020 Oct 30.
To evaluate the role of peak atrial longitudinal strain (PALS) through speckle tracking 2D echocardiography for the assessment of structural and functional left atrial (LA) remodeling in a type 2 diabetes mellitus (T2DM) population.
We conducted a cross-sectional study during a 9-month period. T2DM adults aged 18 and above were included. The variables assessed during the study include age and gender of participants, diabetes characteristics, cardiovascular risk factors, clinical anthropometric and hemodynamic parameters, standard echocardiographic parameters, volume-derived LA functions, and 2D PALS.
We included a total of 102 patients. The mean age was 58 ± 11.7 years, and the M/F sex ratio was 1:1.5. Coexistent arterial hypertension (HTN) was observed in more than half (59.8%) of the population sample. Mean 2D PALS was 29.2 ± 8.9% with 58.8% (95% CI: 50.0-68.6) of subjects having a reduced LA strain (ie,<32%). Reservoir and pump functions were the most altered LA volumetric phasic functions. Mean indexed LA maximal volume was 22.2 ± 6.8 mL/m . There was a significant association between abnormal PALS and age, Body mass index (BMI), indexed LA volume, E/E' ratio, LA active ejection fraction (pump function), and LA expansion index (reservoir function).
Left atrial remodeling is a recurrent condition in adult T2DM Cameroonians. The reservoir and pump LA functions were the most affected. Assessment of LA global strain allows early detection of LA remodeling with comparison to LA size standard analyses. Age, BMI, indexed LA volume, E/E' ratio, and reservoir and pump LA functions were associated to 2D LA global strain impairment.
通过斑点追踪二维超声心动图评估峰值心房纵向应变（PALS）在 2 型糖尿病（T2DM）人群中评估左心房（LA）结构性和功能性重构的作用。
我们进行了一项为期 9 个月的横断面研究。纳入年龄在 18 岁及以上的 T2DM 成年人。研究期间评估的变量包括参与者的年龄和性别、糖尿病特征、心血管危险因素、临床人体测量和血液动力学参数、标准超声心动图参数、容积衍生的 LA 功能和 2D PALS。
我们共纳入了 102 例患者。平均年龄为 58±11.7 岁，男女比例为 1:1.5。超过一半（59.8%）的人群样本存在并存的动脉高血压（HTN）。平均 2D PALS 为 29.2±8.9%，58.8%（95%CI：50.0-68.6）的受试者 LA 应变降低（即<32%）。储备和泵功能是 LA 容积时相功能改变最明显的。平均 indexed LA 最大容积为 22.2±6.8 mL/m 。异常 PALS 与年龄、体重指数（BMI）、indexed LA 容积、E/E'比值、LA 主动射血分数（泵功能）和 LA 扩张指数（储备功能）显著相关。
LA 重构是成年 T2DM 喀麦隆人的常见疾病。储备和泵 LA 功能受影响最大。与 LA 大小标准分析相比，LA 整体应变评估可早期发现 LA 重构。年龄、BMI、indexed LA 容积、E/E'比值以及储备和泵 LA 功能与 2D LA 整体应变受损相关。
