Pontificia Universidad Javeriana, Bogotá, Colombia.
RIBEF Ibero-American Network of Pharmacogenetics & Pharmacogenomics, Badajoz, Extremadura, Spain.
Pharmacogenomics. 2020 Nov;21(17):1227-1236. doi: 10.2217/pgs-2020-0102. Epub 2020 Oct 30.
Interethnic differences in allele frequency have been demonstrated across Latin-American countries. Only one previous study describing genotypes in Colombian population has been performed. Thus, this study aimed to evaluate the genetic variability in a mestizo Colombian population, as well as the similarities and differences concerning other Hispanic mestizo (HM) populations. Two hundred and twelve unrelated healthy Colombian subjects were studied, in which different polymorphisms were analyzed by extra long-PCR and real-time PCR. A high percentage of ultrarapid metabolizers (18.4%) was found, representing the highest frequency calculated within the HM populations studied. However, the percentage of poor metabolizers (4.7%) was similar to those previously reported in HM populations.
跨拉丁美洲国家的研究表明，不同种族间等位基因频率存在差异。仅有一项关于哥伦比亚人群基因型的研究。因此，本研究旨在评估哥伦比亚混血人群的遗传多态性，以及与其他西班牙裔混血人群的相似性和差异性。本研究共纳入 212 例无亲缘关系的健康哥伦比亚个体，通过超长 PCR 和实时 PCR 分析了不同的多态性。结果发现超快代谢者的比例较高（18.4%），这是在所研究的西班牙裔混血人群中计算出的最高频率。然而，弱代谢者的比例（4.7%）与之前在西班牙裔混血人群中报道的相似。
