• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Structural organization of complexes of transfer RNAs with aminoacyl transfer RNA synthetases.转运RNA与氨酰基转运RNA合成酶复合物的结构组织
Nucleic Acids Res. 1977;4(5):1649-65. doi: 10.1093/nar/4.5.1649.
2
Three photo-cross-linked complexes of yeast phenylalanine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases.酵母苯丙氨酸特异性转移核糖核酸与氨酰基转移核糖核酸合成酶的三种光交联复合物。
J Biol Chem. 1975 Jun 25;250(12):4440-4.
3
Study of the role of the acceptor stem in the interactions between tRNAs and aminoacyl-tRNA synthetases.关于tRNA受体茎在tRNA与氨酰-tRNA合成酶相互作用中作用的研究。
Nucleic Acids Res. 1975 Feb;2(2):211-21. doi: 10.1093/nar/2.2.211.
4
Anticodon and acceptor stem nucleotides in tRNA(Gln) are major recognition elements for E. coli glutaminyl-tRNA synthetase.tRNA（谷氨酰胺）中的反密码子和受体茎核苷酸是大肠杆菌谷氨酰胺-tRNA合成酶的主要识别元件。
Nature. 1991 Jul 18;352(6332):258-60. doi: 10.1038/352258a0.
5
Two photo-cross-linked complexes of isoleucine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases.异亮氨酸特异性转移核糖核酸与氨酰基转移核糖核酸合成酶的两种光交联复合物。
J Biol Chem. 1975 Jun 25;250(12):4433-9.
6
[Role of the anticodon in recognition of tRNA by aminoacyl-tRNA-synthetases].[反密码子在氨酰-tRNA合成酶识别tRNA中的作用]
Mol Biol (Mosk). 1983 Sep-Oct;17(5):928-48.
7
Aminoacylation of RNA minihelices: implications for tRNA synthetase structural design and evolution.RNA小螺旋的氨酰化：对氨酰tRNA合成酶结构设计和进化的启示
Crit Rev Biochem Mol Biol. 1993;28(4):309-22. doi: 10.3109/10409239309078438.
8
Transfer RNA recognition by aminoacyl-tRNA synthetases.氨酰-tRNA合成酶对转运RNA的识别
Biopolymers. 1999;52(1):1-28. doi: 10.1002/(SICI)1097-0282(1999)52:1<1::AID-BIP1>3.0.CO;2-W.
9
Rules that govern tRNA identity in protein synthesis.蛋白质合成中决定tRNA识别特异性的规则。
J Mol Biol. 1993 Nov 20;234(2):257-80. doi: 10.1006/jmbi.1993.1582.
10
Enzymatic replacement of the anticodon of yeast phenylalanine transfer ribonucleic acid.酵母苯丙氨酸转移核糖核酸反密码子的酶促置换
Biochemistry. 1982 Mar 2;21(5):855-61. doi: 10.1021/bi00534a007.

引用本文的文献

1
Mamit-tRNA, a database of mammalian mitochondrial tRNA primary and secondary structures.Mamit-tRNA，一个哺乳动物线粒体tRNA一级和二级结构的数据库。
RNA. 2007 Aug;13(8):1184-90. doi: 10.1261/rna.588407. Epub 2007 Jun 21.
2
The early history of tRNA recognition by aminoacyl-tRNA synthetases.氨酰-tRNA合成酶识别tRNA的早期历史。
J Biosci. 2006 Oct;31(4):477-88. doi: 10.1007/BF02705187.
3
The tRNA-like structure of turnip yellow mosaic virus RNA: structural organization of the last 159 nucleotides from the 3' OH terminus.芜菁黄花叶病毒 RNA 的 tRNA 样结构：3' OH 末端最后 159 个核苷酸的结构组织。
EMBO J. 1982;1(2):269-76. doi: 10.1002/j.1460-2075.1982.tb01158.x.
4
Two essential regions for tRNA recognition in Bacillus subtilis tryptophanyl-tRNA synthetase.枯草芽孢杆菌色氨酰-tRNA合成酶中识别tRNA的两个关键区域。
Biochem J. 2002 Aug 1;365(Pt 3):749-56. doi: 10.1042/BJ20020141.
5
Functional communication in the recognition of tRNA by Escherichia coli glutaminyl-tRNA synthetase.大肠杆菌谷氨酰胺-tRNA合成酶识别tRNA过程中的功能交流
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):291-5. doi: 10.1073/pnas.91.1.291.
6
A conformational rationale for the origin of the mechanism of nucleicacid-directed protein synthesis of 'living' organisms.关于“活”生物体核酸指导蛋白质合成机制起源的构象原理。
Orig Life. 1980 Mar;10(1):15-30. doi: 10.1007/BF00928940.
7
Molecular basis for the genetic code.遗传密码的分子基础。
J Mol Evol. 1982;18(5):297-303. doi: 10.1007/BF01733895.
8
Conformational activation of the yeast phenylalanyl-tRNA synthetase catalytic site induced by tRNAPhe interaction: triggering of adenosine or CpCpA trinucleoside diphosphate aminoacylation upon binding of tRNAPhe lacking these residues.由tRNAPhe相互作用诱导的酵母苯丙氨酰-tRNA合成酶催化位点的构象激活：缺乏这些残基的tRNAPhe结合时腺苷或CpCpA三核苷二磷酸氨基酰化的触发。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1606-8. doi: 10.1073/pnas.78.3.1606.
9
Functional assay of tRNA molecules transcribed from a purified gene.对从纯化基因转录而来的tRNA分子进行功能测定。
Nucleic Acids Res. 1982 Nov 25;10(22):7363-72. doi: 10.1093/nar/10.22.7363.
10
Study of the interactions between avian myeloblastosis virus reverse transcriptase and primer tRNA. Affinity labeling and inactivation of the enzyme by periodate-treated tRNATrp.禽成髓细胞瘤病毒逆转录酶与引物tRNA相互作用的研究。经高碘酸盐处理的tRNATrp对该酶的亲和标记及失活作用。
Nucleic Acids Res. 1980 Sep 11;8(17):4009-20. doi: 10.1093/nar/8.17.4009.

本文引用的文献

1
STRUCTURE OF A RIBONUCLEIC ACID.核糖核酸的结构
Science. 1965 Mar 19;147(3664):1462-5. doi: 10.1126/science.147.3664.1462.
2
On the role of soluble ribonucleic acid in coding for amino acids.论可溶性核糖核酸在氨基酸编码中的作用。
Proc Natl Acad Sci U S A. 1962 Jun 15;48(6):1086-92. doi: 10.1073/pnas.48.6.1086.
3
Mischarging in mutant tyrosine transfer RNAs.突变型酪氨酸转运核糖核酸中的错载。
FEBS Lett. 1972 Apr 15;22(1):149-155. doi: 10.1016/0014-5793(72)80241-2.
4
Mutant tyrosine tRNA of altered amino acid specificity.氨基酸特异性改变的突变型酪氨酸转运RNA
FEBS Lett. 1972 Apr 15;22(1):144-148. doi: 10.1016/0014-5793(72)80240-0.
5
Incorrect heterologous aminoacylation of various yeast tRNAS catalysed by E. coli valyl-tRNA synthetase.大肠杆菌缬氨酰 - tRNA合成酶催化的各种酵母tRNA的错误异源氨酰化作用。
FEBS Lett. 1971 Jul 1;15(4):281-285. doi: 10.1016/0014-5793(71)80638-5.
6
Interactions of seryl-tRNA synthetase with serine and phenylalanine specific tRNA.
FEBS Lett. 1970 Dec 18;11(5):320-323. doi: 10.1016/0014-5793(70)80558-0.
7
A specific chemical chain scission of tRNA at 7-methylguanosine.转运核糖核酸（tRNA）在7-甲基鸟苷处的特定化学链断裂。
FEBS Lett. 1970 Dec;11(3):160-164. doi: 10.1016/0014-5793(70)80518-x.
8
Effect of cleaving the dihydrouridine loop and the ribothymidine loop on the amino acid acceptor activity of yeast phenylalanine transfer ribonucleic acid.切割二氢尿嘧啶环和核糖胸腺嘧啶环对酵母苯丙氨酸转移核糖核酸氨基酸接受活性的影响。
J Biol Chem. 1970 Nov 10;245(21):5743-50.
9
Studies concerning the interaction of serine soluble ribonucleic acid with seryl soluble ribonucleic acid synthetase from baker's yeast.关于丝氨酸可溶性核糖核酸与面包酵母的丝氨酰可溶性核糖核酸合成酶相互作用的研究。
Biochemistry. 1966 Jul;5(7):2246-54. doi: 10.1021/bi00871a013.
10
The yeast phenylalanyl-transfer RNA synthetase recognition site: the region adjacent to the dihydrouridine loop.酵母苯丙氨酰 - 转移RNA合成酶识别位点：与二氢尿嘧啶环相邻的区域。
Proc Natl Acad Sci U S A. 1971 Mar;68(3):681-4. doi: 10.1073/pnas.68.3.681.

转运RNA与氨酰基转运RNA合成酶复合物的结构组织

Structural organization of complexes of transfer RNAs with aminoacyl transfer RNA synthetases.

作者信息

Rich A, Schimmel P R

出版信息

Nucleic Acids Res. 1977;4(5):1649-65. doi: 10.1093/nar/4.5.1649.

DOI:10.1093/nar/4.5.1649
PMID:331261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC343779/
Abstract

A variety of experimental data on synthetase-tRNA interactions are examined. Although these data previously had no direct explanation when viewed only in terms of the tRNA cloverleaf diagram, they can be rationalized according to a simple proposal that takes account of the three dimensional structure of tRNA. It is proposed that a major part of the binding site for most or all synthetases is along and around the diagonal side of the tRNA structure, which contains the acceptor stem, dihydrouridine stem, and anticodon. This side of the tRNA molecule contains structural features likely to be common for all tRNAs. Depending on the system, an enzyme may span a small part or all of the region of this side of the molecule. Interactions with other parts of the structure may also occur in a manner that varies from complex to complex. These interactions may be determined, in part, by the angle at which the diagonal side of the flat tRNA molecule is inserted onto the surface of the synthetase.

摘要

对合成酶与tRNA相互作用的各种实验数据进行了研究。尽管这些数据以前仅从tRNA三叶草叶形图的角度来看没有直接的解释，但根据一个考虑了tRNA三维结构的简单提议，它们可以得到合理的解释。有人提出，大多数或所有合成酶的结合位点的主要部分沿着tRNA结构的对角线一侧及其周围，该区域包含受体茎、二氢尿嘧啶茎和反密码子。tRNA分子的这一侧包含所有tRNA可能共有的结构特征。根据系统的不同，一种酶可能跨越分子这一侧区域的一小部分或全部。与结构其他部分的相互作用也可能以因复合物而异的方式发生。这些相互作用可能部分由扁平tRNA分子的对角线一侧插入合成酶表面的角度决定。