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转运RNA与氨酰基转运RNA合成酶复合物的结构组织

Structural organization of complexes of transfer RNAs with aminoacyl transfer RNA synthetases.

作者信息

Rich A, Schimmel P R

出版信息

Nucleic Acids Res. 1977;4(5):1649-65. doi: 10.1093/nar/4.5.1649.

DOI:10.1093/nar/4.5.1649
PMID:331261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC343779/
Abstract

A variety of experimental data on synthetase-tRNA interactions are examined. Although these data previously had no direct explanation when viewed only in terms of the tRNA cloverleaf diagram, they can be rationalized according to a simple proposal that takes account of the three dimensional structure of tRNA. It is proposed that a major part of the binding site for most or all synthetases is along and around the diagonal side of the tRNA structure, which contains the acceptor stem, dihydrouridine stem, and anticodon. This side of the tRNA molecule contains structural features likely to be common for all tRNAs. Depending on the system, an enzyme may span a small part or all of the region of this side of the molecule. Interactions with other parts of the structure may also occur in a manner that varies from complex to complex. These interactions may be determined, in part, by the angle at which the diagonal side of the flat tRNA molecule is inserted onto the surface of the synthetase.

摘要

对合成酶与tRNA相互作用的各种实验数据进行了研究。尽管这些数据以前仅从tRNA三叶草叶形图的角度来看没有直接的解释，但根据一个考虑了tRNA三维结构的简单提议，它们可以得到合理的解释。有人提出，大多数或所有合成酶的结合位点的主要部分沿着tRNA结构的对角线一侧及其周围，该区域包含受体茎、二氢尿嘧啶茎和反密码子。tRNA分子的这一侧包含所有tRNA可能共有的结构特征。根据系统的不同，一种酶可能跨越分子这一侧区域的一小部分或全部。与结构其他部分的相互作用也可能以因复合物而异的方式发生。这些相互作用可能部分由扁平tRNA分子的对角线一侧插入合成酶表面的角度决定。

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