Takatsu Y, Yui Y, Hattori R, Sakaguchi K, Susawa T, Yui N, Kawai C
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Jpn Circ J. 1987 Jun;51(6):611-6. doi: 10.1253/jcj.51.611.
The hemodynamic effect of oral TA-064 (20 mg), a newly synthesized inotropic agent, was compared with that of intravenous dobutamine (5 micrograms/kg/min) in eight patients with congestive heart failure who had been treated with intravenous dobutamine, digitalis, diuretics, and prazosin. Hemodynamics was measured using a Swan-Ganz catheter during the pre-dobutamine control period, during dobutamine infusion period, during the pre-TA-064 control period and at 90 minutes after oral administration of TA-064. Stroke work index was increased and mean pulmonary capillary wedge pressure was decreased with TA-064 or dobutamine. Cardiac index and stroke index was increased by each drug, and pulmonary and systemic vascular resistances were decreased. Mean systemic arterial pressure, heart rate and pressure-rate product did not significantly change in comparison with the control level. In conclusion, TA-064 has a hemodynamic effect similar to that of dobutamine and may be useful as an oral substitute for dobutamine in patients with congestive heart failure after temporary management with dobutamine.
在8例充血性心力衰竭患者中，比较了新合成的正性肌力药物口服TA - 064（20毫克）与静脉注射多巴酚丁胺（5微克/千克/分钟）的血流动力学效应。这些患者此前已接受静脉注射多巴酚丁胺、洋地黄、利尿剂和哌唑嗪治疗。在多巴酚丁胺治疗前的对照期、多巴酚丁胺输注期、TA - 064治疗前的对照期以及口服TA - 064后90分钟，使用Swan - Ganz导管测量血流动力学。TA - 064或多巴酚丁胺可使每搏功指数增加，平均肺毛细血管楔压降低。每种药物均可使心脏指数和每搏指数增加，肺血管和体循环血管阻力降低。与对照水平相比，平均体循环动脉压、心率和压力 - 心率乘积无显著变化。总之，TA - 064具有与多巴酚丁胺相似的血流动力学效应，在充血性心力衰竭患者经多巴酚丁胺临时治疗后，TA - 064可用作多巴酚丁胺的口服替代药物。
