Level 7, Newborn Research, Royal Women's Hospital, 20 Flemington Road, Parkville, VIC 3052, Australia; Level 7, Dept of Obstetrics & Gynaecology, University of Melbourne, Royal Women's Hospital, 20 Flemington Road, Parkville, VIC 3052, Australia; Clinical Sciences, Murdoch Children's Research Institute, Parkville, VIC 3052, Australia.
Level 7, Dept of Obstetrics & Gynaecology, University of Melbourne, Royal Women's Hospital, 20 Flemington Road, Parkville, VIC 3052, Australia; Clinical Sciences, Murdoch Children's Research Institute, Parkville, VIC 3052, Australia; Department of Paediatrics, The University of Melbourne, Parkville, VIC 3052, Australia.
Semin Fetal Neonatal Med. 2020 Dec;25(6):101158. doi: 10.1016/j.siny.2020.101158. Epub 2020 Oct 21.
Caffeine to prevent or treat apnea of prematurity in the newborn period is now standard of care for infants born very preterm. It has both short- and longer-term effects on respiratory health. In the short-term it reduces the duration of assisted ventilation and of oxygen therapy. It also reduces the rate of treatment for a patent ductus arteriosus, and of bronchopulmonary dysplasia. In the longer-term it improves expiratory airflow in childhood, and may have some benefits on respiratory health. Because it has not been used as a neonatal treatment for long enough, it is unknown if neonatal caffeine treatment has any effects on adult expiratory airflow, or on chronic obstructive pulmonary disease in later adult life.
咖啡因预防或治疗早产儿呼吸暂停已成为极早产儿常规治疗手段。它对呼吸健康既有短期影响也有长期影响。短期来看，它可以减少辅助通气和氧疗的持续时间。它还降低了动脉导管未闭和支气管肺发育不良的治疗率。长期来看，它可以改善儿童时期呼气气流，并且可能对呼吸健康有一些益处。由于新生儿咖啡因治疗使用时间不够长，尚不清楚新生儿咖啡因治疗是否对成人呼气气流或成年后慢性阻塞性肺疾病有任何影响。
