Regenerative and Restorative Medicine Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey.
Regenerative and Restorative Medicine Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey; Department of Neurology, Alanya Alaaddin Keykubat University, Antalya, Turkey; Department of Neurology, Istanbul Medipol University, Istanbul, Turkey.
Neurosci Lett. 2021 Jan 1;740:135444. doi: 10.1016/j.neulet.2020.135444. Epub 2020 Oct 28.
Charles Bonnet Syndrome (CBS) is a rare clinical condition which has been defined as complex visual hallucinations (CVH) due to visual loss. This study investigated differences in the EEG power spectral density (PSD) and magnitude-squared coherences between patients with eye disease and hallucinations (VH+), and the control subjects with eye disease without hallucinations (VH-).
19 scalp channels EEG was recorded in four VH+ (CBS) and four VH- subjects during an eyes-closed resting condition. Artefact-free epochs were analyzed to obtain PSD values in the delta, theta, alpha1, alpha2, beta1, beta2 and gamma frequency bands. Coherence values were calculated through inter-hemispheric and intra-hemispheric electrodes pairs of interest. All subjects were performed with neuropsychological and behavioral assessments to evaluate cognitive functions.
The VH + group had increase PSD in theta, beta2 and gamma bands in central, parietal and occipital (O2) areas. The synchronicity was altered particularly in parietal and frontal-parietal regions especially at theta and alpha1 respectively.
The aberrant activity in occipital and parietal regions suggest the mechanism of CBS. This is a major electrophysiological study of understanding CBS and visual hallucinations.
Charles Bonnet 综合征（CBS）是一种罕见的临床病症，其特征为视觉丧失所致的复杂视觉幻觉（CVH）。本研究旨在比较伴有视觉幻觉（VH+）和不伴有视觉幻觉（VH-）的眼病患者之间的脑电功率谱密度（PSD）和平方相干值的差异。
在闭眼休息状态下，对 4 名 VH+（CBS）和 4 名 VH-患者进行 19 通道头皮脑电图记录。分析无伪迹的脑电数据，以获取 delta、theta、alpha1、alpha2、beta1、beta2 和 gamma 频段的 PSD 值。通过感兴趣的半球间和半球内电极对计算相干值。对所有患者进行神经心理学和行为评估，以评估认知功能。
VH+组在中央、顶叶和枕叶（O2）区域的 theta、beta2 和 gamma 频段的 PSD 增加。同步性改变主要发生在顶叶和额顶叶区域，分别在 theta 和 alpha1 频段。
枕叶和顶叶区域的异常活动提示 CBS 的发病机制。这是一项重要的理解 CBS 和视觉幻觉的电生理研究。
