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Post-transplantation cyclophosphamide restores early B-cell lymphogenesis that suppresses subsequent chronic graft-versus-host disease.

作者信息

Iwamoto Miki, Ikegawa Shuntaro, Kondo Takumi, Meguri Yusuke, Nakamura Makoto, Sando Yasuhisa, Sugiura Hiroyuki, Sumii Yuichi, Asada Noboru, Ennishi Daisuke, Nishimori Hisakazu, Fujii Keiko, Fujii Nobuharu, Shibakura Misako, Maeda Yoshinobu, Matsuoka Ken-Ichi

机构信息

Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Department of Medical Technology, Okayama University Graduate School of Health Sciences, Okayama, Japan.

出版信息

Bone Marrow Transplant. 2021 Apr;56(4):956-959. doi: 10.1038/s41409-020-01100-0. Epub 2020 Oct 30.

DOI:10.1038/s41409-020-01100-0
PMID:33128029
Abstract
摘要

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Post-transplantation cyclophosphamide restores early B-cell lymphogenesis that suppresses subsequent chronic graft-versus-host disease.移植后环磷酰胺可恢复早期B细胞淋巴细胞生成，从而抑制随后的慢性移植物抗宿主病。
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Reduced-Intensity Conditioning with Fludarabine, Cyclophosphamide, and Rituximab Is Associated with Improved Outcomes Compared with Fludarabine and Busulfan after Allogeneic Stem Cell Transplantation for B Cell Malignancies.对于B细胞恶性肿瘤患者，在异基因干细胞移植后，与氟达拉滨和白消安相比，使用氟达拉滨、环磷酰胺和利妥昔单抗进行减低强度预处理与更好的预后相关。
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Posttransplant Cyclophosphamide and Antithymocyte Globulin versus Posttransplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis for Peripheral Blood Stem Cell Haploidentical Transplants: Comparison of T Cell and NK Effector Reconstitution.异基因外周血造血干细胞移植中移植后环磷酰胺和抗胸腺细胞球蛋白与环磷酰胺预防移植物抗宿主病的比较：T 细胞和 NK 效应细胞重建的比较。
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Impressive Graft-versus-Host Disease-Free, Relapse-Free Survival in Matched Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning and a Combination of Antithymocyte Globulin and Post-Transplantation Cyclophosphamide.使用减低剂量预处理以及抗胸腺细胞球蛋白与移植后环磷酰胺联合方案的单倍体相合异基因造血干细胞移植中，实现了令人瞩目的无移植物抗宿主病、无复发生存。
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MedComm (2020). 2025 May 19;6(6):e70206. doi: 10.1002/mco2.70206. eCollection 2025 Jun.
2
Immunological reconstitution and infections after alloHCT - a comparison between post-transplantation cyclophosphamide, ATLG and non-ATLG based GvHD prophylaxis.异基因造血干细胞移植后的免疫重建与感染——移植后环磷酰胺、抗胸腺细胞球蛋白和基于非抗胸腺细胞球蛋白的移植物抗宿主病预防措施的比较
Bone Marrow Transplant. 2025 Mar;60(3):286-296. doi: 10.1038/s41409-024-02474-1. Epub 2024 Nov 19.
3

本文引用的文献

1
Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets.慢性移植物抗宿主病的病理生理学及治疗靶点
N Engl J Med. 2017 Dec 28;377(26):2565-2579. doi: 10.1056/NEJMra1703472.
2
Ibrutinib for chronic graft-versus-host disease after failure of prior therapy.伊布替尼用于既往治疗失败后的慢性移植物抗宿主病。
Blood. 2017 Nov 23;130(21):2243-2250. doi: 10.1182/blood-2017-07-793786. Epub 2017 Sep 18.
3
Circulating T follicular helper cells with increased function during chronic graft-versus-host disease.慢性移植物抗宿主病期间功能增强的循环滤泡辅助性T细胞。
Haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide for Fanconi anemia with/without anti-thymocyte globulin.
采用移植后环磷酰胺联合或不联合抗胸腺细胞球蛋白的单倍体相合造血干细胞移植治疗范可尼贫血
Blood Cell Ther. 2024 Aug 9;7(3):95-100. doi: 10.31547/bct-2024-006. eCollection 2024 Aug 25.
4
Immunopathogenic mechanisms and modulatory approaches to graft-versus-host disease prevention in acute myeloid leukaemia.免疫发病机制及调控策略在急性髓系白血病移植物抗宿主病预防中的作用。
Best Pract Res Clin Haematol. 2023 Jun;36(2):101475. doi: 10.1016/j.beha.2023.101475. Epub 2023 May 11.
5
Novel insights into GVHD and immune reconstitution after allogeneic hematopoietic cell transplantation.异基因造血细胞移植后移植物抗宿主病和免疫重建的新见解。
Blood Cell Ther. 2023 Apr 21;6(2):42-48. doi: 10.31547/bct-2022-023. eCollection 2023 May 25.
6
Hematopoietic stem cell-derived Tregs are essential for maintaining favorable B cell lymphopoiesis following posttransplant cyclophosphamide.造血干细胞衍生的 Tregs 对于移植后环磷酰胺治疗后维持有利的 B 细胞淋巴生成至关重要。
JCI Insight. 2023 Apr 24;8(8):e162180. doi: 10.1172/jci.insight.162180.
7
Impact of GVHD prophylaxis on CMV reactivation and disease after HLA-matched peripheral blood stem cell transplantation.异基因造血干细胞移植后，移植物抗宿主病预防对 CMV 再激活和疾病的影响。
Blood Adv. 2023 Apr 25;7(8):1394-1403. doi: 10.1182/bloodadvances.2022009112.
8
Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant.移植后环磷酰胺改变免疫特征，并导致异基因造血干细胞移植后 T 细胞重建受损。
J Hematol Oncol. 2022 May 19;15(1):64. doi: 10.1186/s13045-022-01287-3.
9
Harnessing Treg Homeostasis to Optimize Posttransplant Immunity: Current Concepts and Future Perspectives.利用调节性 T 细胞（Treg）的内稳态来优化移植后免疫：当前概念和未来展望。
Front Immunol. 2021 Aug 30;12:713358. doi: 10.3389/fimmu.2021.713358. eCollection 2021.
10
Immune reconstitution after T-cell replete HLA haploidentical hematopoietic stem cell transplantation using high-dose post-transplant cyclophosphamide.高剂量移植后环磷酰胺用于 T 细胞充足 HLA 单倍体相合造血干细胞移植后的免疫重建。
J Clin Exp Hematop. 2021 Mar 18;61(1):1-9. doi: 10.3960/jslrt.20040. Epub 2021 Feb 6.
Blood. 2016 May 19;127(20):2489-97. doi: 10.1182/blood-2015-12-688895. Epub 2016 Mar 4.
4
Ibrutinib treatment ameliorates murine chronic graft-versus-host disease.依鲁替尼治疗可改善小鼠慢性移植物抗宿主病。
J Clin Invest. 2014 Nov;124(11):4867-76. doi: 10.1172/JCI75328. Epub 2014 Oct 1.
5
Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT.急性移植物抗宿主病期间骨髓 T 细胞浸润与 HSCT 后 B 细胞恢复和功能延迟有关。
Blood. 2014 Aug 7;124(6):963-72. doi: 10.1182/blood-2013-11-539031. Epub 2014 May 15.
6
Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans.慢性移植物抗宿主病和闭塞性细支气管炎需要增加滤泡辅助性T细胞和生发中心B细胞。
Blood. 2014 Jun 19;123(25):3988-98. doi: 10.1182/blood-2014-03-562231. Epub 2014 May 12.
7
Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide.醛脱氢酶表达促使人类调节性T细胞对移植后环磷酰胺产生抗性。
Sci Transl Med. 2013 Nov 13;5(211):211ra157. doi: 10.1126/scitranslmed.3006960.
8
Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence.异基因移植后预防性使用利妥昔单抗可降低 B 细胞同种异体免疫反应，慢性移植物抗宿主病发生率低。
Blood. 2012 Jun 21;119(25):6145-54. doi: 10.1182/blood-2011-12-395970. Epub 2012 May 4.
9
Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease.人类慢性移植物抗宿主病中B细胞稳态改变与BAFF过量
Blood. 2009 Apr 16;113(16):3865-74. doi: 10.1182/blood-2008-09-177840. Epub 2009 Jan 23.
10
High levels of B-cell activating factor in patients with active chronic graft-versus-host disease.活动性慢性移植物抗宿主病患者体内B细胞活化因子水平较高。
Clin Cancer Res. 2007 Oct 15;13(20):6107-14. doi: 10.1158/1078-0432.CCR-07-1290.