Barzilay J, Kushtai G, Plaksin D, Feldman M, Eisenbach L
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Leukemia. 1987 Mar;1(3):198-204.
The relationship between the expression of the c-fos proto-oncogene and the expression of the class I major histocompatibility (MHC) antigens during the early stages of induced differentiation in three different leukemic cell lines was examined. In the U937 histiocytic lymphoma line TPA induced an increase in mRNA and cell surface MHC expression which followed induction of c-fos. In contrast, in the murine erythro-leukemia cell line, DMSO induced declining constitutive c-fos levels that were accompanied by declining mRNA and cell surface MHC expression. In the pluripotent HL60 promyelocytic line induction of macrophage differentiation with TPA led to c-fos induction and rising MHC levels, whereas induction of granulocyte differentiation with DMSO did not induce c-fos expression and was followed by declining MHC levels. Taken together, the results suggest that the c-fos proto-oncogene might be involved in the control of class I MHC antigen expression during differentiation.
研究了三种不同白血病细胞系诱导分化早期阶段c-fos原癌基因表达与I类主要组织相容性（MHC）抗原表达之间的关系。在U937组织细胞淋巴瘤细胞系中，佛波酯（TPA）诱导mRNA和细胞表面MHC表达增加，这发生在c-fos诱导之后。相反，在小鼠红白血病细胞系中，二甲基亚砜（DMSO）诱导组成型c-fos水平下降，同时mRNA和细胞表面MHC表达也下降。在多能HL60早幼粒细胞系中，用TPA诱导巨噬细胞分化导致c-fos诱导和MHC水平升高，而用DMSO诱导粒细胞分化未诱导c-fos表达，随后MHC水平下降。综上所述，结果表明c-fos原癌基因可能参与分化过程中I类MHC抗原表达的调控。
