Department of Periodontology, Faculty of Dentistry, Giresun University, Giresun, Turkey.
Department of Periodontology, Faculty of Dentistry, Bulent Ecevit University, Zonguldak, Turkey.
J Periodontol. 2021 Jan;92(1):104-112. doi: 10.1002/JPER.20-0358. Epub 2020 Nov 18.
Leucine-rich alpha-2 glycoprotein (LRG) is a novel acute phase protein involved in inflammation-associated diseases and that considered to be induced by multiple proinflammatory cytokines. This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with Stage 3 periodontitis before and after non-surgical periodontal treatment.
Twenty-five Stage 3 periodontitis and twenty-five periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were obtained at baseline and at 6 weeks after treatment. LRG, IL-6 and TNF-α were determined by ELISA.
GCF and serum LRG, IL-6 and TNF-α were significantly higher in periodontitis group than healthy controls (P < .001). A significant decrease in GCF and serum LRG, IL-6 and TNF-α was detected after periodontal treatment compared with baseline values of periodontitis patients (P < .001).
Our findings revealed that LRG expression was increased in Stage 3 periodontitis both locally and systemically, and non-surgical periodontal therapy was effective in reducing LRG levels in GCF and serum of these patients.
富含亮氨酸的α-2 糖蛋白（LRG）是一种新型的急性期蛋白，参与炎症相关疾病，被认为是由多种促炎细胞因子诱导产生的。本研究旨在探讨 3 期牙周炎患者牙周非手术治疗前后龈沟液（GCF）和血清 LRG、白细胞介素（IL）-6 和肿瘤坏死因子（TNF）-α水平。
本研究纳入 25 名 3 期牙周炎患者和 25 名牙周健康者。记录临床牙周测量值；牙周炎患者接受牙周非手术治疗，分别于基线和治疗后 6 周采集 GCF 和血清样本。采用 ELISA 法检测 LRG、IL-6 和 TNF-α。
牙周炎组 GCF 和血清 LRG、IL-6 和 TNF-α明显高于健康对照组（P<.001）。与牙周炎患者的基线值相比，牙周治疗后 GCF 和血清 LRG、IL-6 和 TNF-α显著降低（P<.001）。
我们的研究结果表明，LRG 在 3 期牙周炎中无论是局部还是全身都呈高表达，牙周非手术治疗能有效降低这些患者 GCF 和血清中的 LRG 水平。
