Liu Na, Zakrzewski Jessica J, Mathews Carol A, Keil Andreas
Department of Psychiatry, Center for OCD, Anxiety, and Related Disorders, College of Medicine, University of Florida, Gainesville, FL, USA.
Department of Medical Psychology, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, China.
Psychophysiology. 2021 Feb;58(2):e13711. doi: 10.1111/psyp.13711. Epub 2020 Oct 31.
Individuals with hoarding disorder (HD) typically perform worse than peers on neuropsychological tasks involving visual perception. Functional neuroimaging shows diffusely increased activity in the visual cortex, consistent with inefficient visual processing in HD. The temporal locus of these inefficiencies in HD is unknown. This study examined the temporal unfolding of visual event-related brain potentials (ERPs) to help better define the neurophysiological mechanisms underlying visual dysfunction in HD. Thirty-three individuals with HD and 35 healthy controls (HC) were assessed using a 64-channel EEG during a modified flanker task. Permutation-controlled analyses were conducted to detect group differences in visual evoked ERPs on a millisecond-to-millisecond basis. Bayesian ANCOVAs and linear regressions that included hoarding and age were conducted to identify the best-fit model for the identified VEPs, compared to a null model that included depression and anxiety severity. Three temporal regions (175 ms, 270 ms, and 440 ms), showed differences in amplitude between HD and HC and were consistent with ERP components N1, P1/N2, and a late negative slow wave (LNSW), respectively. After controlling for depression and anxiety, HD demonstrated an enhanced ERP amplitude at N1 and an attenuated amplitude in LNSW compared to HC but did not show differences at P1/N2. For the N1 and LNSW, there was also a primary effect of the interaction between hoarding and age. This study indicates that altered visuocortical reactivity in HD first occurs at the level of visuocortical processing after 170 ms, indicating alterations of middle and later, but not early, processing in occipitotemporal visual cortex.
患有囤积障碍（HD）的个体在涉及视觉感知的神经心理学任务上的表现通常比同龄人差。功能性神经成像显示视觉皮层的活动普遍增加，这与HD中低效的视觉处理一致。HD中这些低效现象的时间定位尚不清楚。本研究检查了视觉事件相关脑电位（ERP）的时间展开情况，以帮助更好地定义HD中视觉功能障碍背后的神经生理机制。在一项改良的侧翼任务中，使用64通道脑电图对33名HD个体和35名健康对照者（HC）进行了评估。进行了置换控制分析，以逐毫秒检测视觉诱发ERP中的组间差异。进行了包括囤积和年龄的贝叶斯协方差分析和线性回归，以确定所识别的视觉诱发电位的最佳拟合模型，并与包括抑郁和焦虑严重程度的零模型进行比较。三个时间区域（175毫秒、270毫秒和440毫秒）显示HD和HC之间的振幅存在差异，分别与ERP成分N1、P1/N2和晚期负向慢波（LNSW）一致。在控制了抑郁和焦虑之后，与HC相比，HD在N1处的ERP振幅增强，在LNSW处的振幅减弱，但在P1/N2处没有差异。对于N1和LNSW，囤积和年龄之间的相互作用也有主要影响。这项研究表明，HD中视觉皮层反应性的改变首先发生在170毫秒后的视觉皮层处理水平，表明枕颞视觉皮层的中晚期而非早期处理发生了改变。
