椎体神经消融术治疗椎源性疼痛
Basivertebral Nerve Ablation for the Treatment of Vertebrogenic Pain.
作者信息
Urits Ivan, Noor Nazir, Johal Arjun Singh, Leider Joseph, Brinkman Joseph, Fackler Nathan, Vij Neeraj, An Daniel, Cornett Elyse M, Kaye Alan D, Viswanath Omar
机构信息
Beth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Boston, MA, USA.
Department of Anesthesiology, Mount Sinai Medical Center of Florida, Miami, FL, USA.
出版信息
Pain Ther. 2021 Jun;10(1):39-53. doi: 10.1007/s40122-020-00211-2. Epub 2020 Oct 31.
Abstract
Chronic low back pain affects a significant portion of patients worldwide and is a major contributor to patient disability; however, it is a difficult problem to diagnose and treat. The prevailing model of chronic low back pain has presumed to follow a discogenic model, but recent studies have shown a vertebrogenic model that involves the basivertebral nerve (BVN). Radiofrequency ablation of the BVN has emerged as a possible nonsurgical therapy for vertebrogenic low back pain. The objective of this manuscript is to provide a comprehensive review of vertebrogenic pain diagnosis and our current understanding of BVN ablation as treatment.
摘要
慢性下腰痛影响着全球相当一部分患者，是导致患者残疾的主要原因；然而，它是一个难以诊断和治疗的问题。慢性下腰痛的主流模型一直假定遵循椎间盘源性模型，但最近的研究显示了一种涉及椎基底神经（BVN）的椎体源性模型。BVN射频消融已成为椎体源性下腰痛一种可能的非手术治疗方法。本文的目的是对椎体源性疼痛的诊断以及我们目前对BVN消融治疗的理解进行全面综述。
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JOR Spine. 2020 Feb 19;3(1):e1083. doi: 10.1002/jsp2.1083. eCollection 2020 Mar.
2
International Society for the Advancement of Spine Surgery Guideline-Intraosseous Ablation of the Basivertebral Nerve for the Relief of Chronic Low Back Pain.国际脊柱手术进展协会指南——经椎体内消融椎基神经以缓解慢性下腰痛
Int J Spine Surg. 2020 Feb 29;14(1):18-25. doi: 10.14444/7002. eCollection 2020 Feb.
3
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Spine J. 2020 Feb;20(2):154-155. doi: 10.1016/j.spinee.2019.10.002.
4
Answer to the letter to the editor of Y. Li et al. concerning "Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham-controlled multi-center study" by Fischgrund JS, et al. [Eur Spine J; (2018) 27(5): 1146-1156].对Y. Li等人致编辑信的回复，该信涉及Fischgrund JS等人的“经皮椎体基底部神经消融术治疗慢性下腰痛：一项前瞻性随机双盲假对照多中心研究”[《欧洲脊柱杂志》；(2018) 27(5): 1146 - 1156] 。
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