Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, China; School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China.
Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2021 Feb 15;247:119084. doi: 10.1016/j.saa.2020.119084. Epub 2020 Oct 22.
Herein, a luminescent water-stable terbium-based metal-organic framework (MOF) {Tb(Cmdcp)(HO)·5HO} (1, HCmdcpBr = N-carboxymethyl-(3,5-dicarboxyl)pyridinium bromide) has been synthesized and used for the recyclable sensing of PO and Al in tandem. MOF 1 acts as a fluorescent sensor for PO by the luminescence "turn-off" mechanism with high selectivity over other anions, such as F, Cl, Br, I, NO, HPO, HSO, HCO, HSO, SO, CO and HPO. The formed PO@1 complex further acts as the Al sensor with the luminescence "turn-on" mechanism, also with high selectivity over diverse inorganic cations of Fe, Mn, Co, Ni, Hg, Na, K, Li, Ag, Mg, Ca, Cd, Pb, Cu, and Zn. The detection process for both PO and Al can be directly observed with naked eyes under the UV light at 365 nm. The detection limits for PO and Al are 1.1 μM and 6.6 μM, respectively. Such a sensing cycle is further transferable to urine and serum samples with a satisfactory near-quantitative recovery, highlighting its good potential in biologically relevant applications.
本文合成了一种发光稳定的基于铽的金属有机骨架（MOF）{Tb(Cmdcp)(HO)·5H_2O}（1，HCmdcpBr = N-羧甲基-（3,5-二羧基）吡啶溴盐），并将其用于串联的 PO 和 Al 的可回收传感。MOF 1 通过发光“关闭”机制对 PO 具有高选择性，用作 PO 的荧光传感器，对其他阴离子，如 F、Cl、Br、I、NO、HPO、HSO、HCO、HSO、SO、CO 和 HPO 具有高选择性。形成的 PO@1 配合物进一步作为 Al 传感器，具有发光“开启”机制，对 Fe、Mn、Co、Ni、Hg、Na、K、Li、Ag、Mg、Ca、Cd、Pb、Cu 和 Zn 等多种无机阳离子也具有高选择性。在 365nm 的紫外光下，可以用肉眼直接观察到对 PO 和 Al 的检测过程。PO 和 Al 的检测限分别为 1.1μM 和 6.6μM。这种传感循环可以进一步转移到尿液和血清样本中，具有令人满意的近乎定量的回收率，突出了其在生物相关应用中的良好潜力。
