Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi," University of Messina, Messina, Italy.
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Am J Perinatol. 2022 Jun;39(8):824-829. doi: 10.1055/s-0040-1719151. Epub 2020 Oct 31.
Hypoxic-ischemic encephalopathy (HIE) is the main cause of long-term neurodevelopmental morbidity in term born infants worldwide. Melatonin is a hormone with antioxidant and anti-inflammatory effects that make it a promising molecule for the treatment of perinatal asphyxia. Probably, the synergistic use of hypothermia associated with melatonin treatment may improve the neurological outcome in infants with HIE. In the past 20 years, the efficacy of melatonin in reducing oxidative stress has been demonstrated in animals; however, clinical trials with sufficient sample size of newborns are lacking to date. Since in 2000 we were among the first to study the neuroprotective properties of melatonin on infants, in this review, we want to summarize the advantages and limitations of the investigations conducted to date. KEY POINTS: · HIE is the main cause of morbidity in term born infants worldwide.. · Melatonin is a promising molecule for the treatment of perinatal asphyxia.. · This review summarizes advantages and limitations of the investigations conducted on melatonin..
缺氧缺血性脑病（HIE）是全球足月出生婴儿长期神经发育发病率的主要原因。褪黑素是一种具有抗氧化和抗炎作用的激素，使其成为治疗围产期窒息的有前途的分子。可能，低温与褪黑素治疗的联合使用可能会改善 HIE 婴儿的神经结局。在过去的 20 年中，褪黑素在减轻氧化应激方面的功效已在动物中得到证实；然而，迄今为止，缺乏针对新生儿的足够样本量的临床试验。自 2000 年以来，我们一直是首批研究褪黑素对婴儿的神经保护特性的研究人员之一，在这篇综述中，我们想总结迄今为止进行的研究的优缺点。要点：· HIE 是全球足月出生婴儿发病率的主要原因。· 褪黑素是治疗围产期窒息的有前途的分子。· 本综述总结了褪黑素研究的优缺点。
