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非编码 RNA 在新冠疫情时代的心血管疾病中的作用。

Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era.

机构信息

Molecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, 20097, Milan, Italy.

Laboratory of Epigenetics, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, Italy.

出版信息

J Transl Med. 2020 Oct 31;18(1):408. doi: 10.1186/s12967-020-02582-8.

DOI:10.1186/s12967-020-02582-8
PMID:33129318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7602761/
Abstract

COronaVIrus Disease 19 (COVID-19) is caused by the infection of the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Although the main clinical manifestations of COVID-19 are respiratory, many patients also display acute myocardial injury and chronic damage to the cardiovascular system. Understanding both direct and indirect damage caused to the heart and the vascular system by SARS-CoV-2 infection is necessary to identify optimal clinical care strategies. The homeostasis of the cardiovascular system requires a tight regulation of the gene expression, which is controlled by multiple types of RNA molecules, including RNA encoding proteins (messenger RNAs) (mRNAs) and those lacking protein-coding potential, the noncoding-RNAs. In the last few years, dysregulation of noncoding-RNAs has emerged as a crucial component in the pathophysiology of virtually all cardiovascular diseases. Here we will discuss the potential role of noncoding RNAs in COVID-19 disease mechanisms and their possible use as biomarkers of clinical use.

摘要

冠状病毒病 19（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）感染引起的。虽然 COVID-19 的主要临床表现为呼吸道症状，但许多患者也表现出急性心肌损伤和心血管系统的慢性损害。了解 SARS-CoV-2 感染对心脏和血管系统造成的直接和间接损害对于确定最佳的临床治疗策略是必要的。心血管系统的内稳态需要对基因表达进行严格的调控，这是由多种类型的 RNA 分子控制的，包括编码蛋白质的 RNA（信使 RNA）（mRNAs）和缺乏蛋白编码能力的非编码-RNA。在过去的几年中，非编码-RNA 的失调已成为几乎所有心血管疾病病理生理学的一个关键组成部分。在这里，我们将讨论非编码 RNA 在 COVID-19 疾病机制中的潜在作用及其作为临床应用生物标志物的可能用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/b346a96adbed/12967_2020_2582_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/44c80a9d6d76/12967_2020_2582_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/99314288ff32/12967_2020_2582_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/21cef5314902/12967_2020_2582_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/543fb5f56783/12967_2020_2582_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/b346a96adbed/12967_2020_2582_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/44c80a9d6d76/12967_2020_2582_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/99314288ff32/12967_2020_2582_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/21cef5314902/12967_2020_2582_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/543fb5f56783/12967_2020_2582_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f45/7603677/b346a96adbed/12967_2020_2582_Fig5_HTML.jpg

相似文献

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Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era.

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[4]
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[7]
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[8]
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引用本文的文献

[1]
LEF1-AS1 Deregulation in the Peripheral Blood of Patients with Persistent Post-COVID Symptoms.

Int J Mol Sci. 2025-5-17

[2]
The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives.

Geroscience. 2025-2

[3]
Progress and trends in myocardial infarction-related long non-coding RNAs: a bibliometric analysis.

Front Mol Biosci. 2024-7-29

[4]
A systematic review of non-coding RNA therapeutics in early clinical trials: a new perspective against cancer.

J Transl Med. 2024-8-5

[5]
HCG18, LEF1AS1 and lncCEACAM21 as biomarkers of disease severity in the peripheral blood mononuclear cells of COVID-19 patients.

J Transl Med. 2023-10-26

[6]
Alterations in Circulating miRNA Levels after Infection with SARS-CoV-2 Could Contribute to the Development of Cardiovascular Diseases: What We Know So Far.

Int J Mol Sci. 2023-1-25

[7]
Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality.

Sci Rep. 2022-11-21

[8]
Insights into Cardiovascular Defects and Cardiac Epigenome in the Context of COVID-19.

Epigenomes. 2022-4-21

[9]
SARS-CoV-2, Cardiovascular Diseases, and Noncoding RNAs: A Connected Triad.

Int J Mol Sci. 2021-11-12

[10]
Non-coding RNAs and their bioengineering applications for neurological diseases.

Bioengineered. 2021-12

本文引用的文献

[1]
SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.

Sci Transl Med. 2021-4-21

[2]
Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection.

Nat Commun. 2020-12-9

[3]
Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection.

Future Virol. 2020-9

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SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes.

Cardiovasc Res. 2020-12-1

[5]
Differential microRNA expression in the peripheral blood from human patients with COVID-19.

J Clin Lab Anal. 2020-9-22

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A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors.

Cell Rep. 2020-9-3

[7]
MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes.

J Mol Cell Cardiol. 2020-11

[8]
Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection.

Cell Rep Med. 2020-7-21

[9]
COVID-19: fighting the invisible enemy with microRNAs.

Expert Rev Anti Infect Ther. 2021-2

[10]
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

Cell. 2020-8-5

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