CGRP 受体拮抗剂在 COVID-19 中的应用：潜在的心肺不良影响。
CGRP Receptor Antagonism in COVID-19: Potential Cardiopulmonary Adverse Effects.
机构信息
Institute of Veterinary Physiology and Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
Department of Fundamental Neurobiology, Krembil Research Institute, University Health Network, University of Toronto, Toronto, Canada; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Canada; Group of Brain Vasculature and Neurovascular Unit, Division of Neurosurgery, Department of Clinical Neurosciences, University Hospital Geneva, Geneva, Switzerland; Group of CNS Angiogenesis and Neurovascular Link, Institute for Regenerative Medicine, Neuroscience Center Zürich, University Hospital Zürich, Zürich, Switzerland; Division of Neurosurgery, University Hospital Zürich, Zürich, Switzerland.
出版信息
Trends Mol Med. 2021 Jan;27(1):7-10. doi: 10.1016/j.molmed.2020.10.005. Epub 2020 Oct 22.
Abstract
Recently, the US FDA has authorized a drug repurposing trial with calcitonin gene-related peptide (CGRP) receptor antagonists to reduce lung inflammation in coronavirus 2019 (COVID-19). However, the well-established cardiopulmonary protective effects of CGRP raise concerns about the safety of antagonizing CGRP in COVID-19. Awareness regarding potential cardiopulmonary adverse effects may enable their early detection and prevent illness from worsening.
摘要
最近，美国食品和药物管理局批准了一项使用降钙素基因相关肽（CGRP）受体拮抗剂的药物重新定位试验，以减少 2019 年冠状病毒（COVID-19）引起的肺部炎症。然而，CGRP 已被证实的心肺保护作用引起了人们对在 COVID-19 中拮抗 CGRP 的安全性的担忧。对潜在心肺不良影响的认识可能使其早期发现，并防止病情恶化。
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