Department of Pediatrics/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Int J Infect Dis. 2021 Jan;102:196-202. doi: 10.1016/j.ijid.2020.10.059. Epub 2020 Oct 28.
A novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) has been confirmed as having the capacity to transmit from humans to humans, causing acute respiratory distress syndrome (ARDS) and acute lung injury. Angiotensin converting enzyme-2 (ACE2) is known to be expressed on type II pneumocytes. As a counter-regulatory arm of the renin-angiotensin system (RAS), ACE2 plays critical roles in the pathogenesis of ARDS and acute lung injury. The affinity of the spike protein receptor binding domain (RBD) of SARS-CoV-2 for human ACE2 (hACE2) largely determines the degree of clinical symptoms after infection by SARS-CoV-2. Previous studies have shown that regulating the ACE2/RAS system is effective in the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV)-induced ARDS and acute lung injury. Since ACE2 is the host cell receptor for both SARS-CoV-2 and SARS-CoV, regulating the ACE2/RAS system may alleviate ARDS and acute lung injury caused by SARS-CoV-2 as well as SARS-CoV. Vitamin D was found to affect ACE2, the target of SARS-CoV-2; therefore, we propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2.
一种新型冠状病毒（严重急性呼吸系统综合症冠状病毒 2，SARS-CoV-2）已被证实能够在人与人之间传播，导致急性呼吸窘迫综合征（ARDS）和急性肺损伤。血管紧张素转换酶-2（ACE2）已知存在于 II 型肺泡细胞上。作为肾素-血管紧张素系统（RAS）的一种反向调节臂，ACE2 在 ARDS 和急性肺损伤的发病机制中发挥着关键作用。SARS-CoV-2 的刺突蛋白受体结合域（RBD）与人类 ACE2（hACE2）的亲和力在很大程度上决定了感染 SARS-CoV-2 后的临床症状严重程度。先前的研究表明，调节 ACE2/RAS 系统对治疗严重急性呼吸系统综合症冠状病毒（SARS-CoV）引起的 ARDS 和急性肺损伤有效。由于 ACE2 是 SARS-CoV-2 和 SARS-CoV 的宿主细胞受体，因此调节 ACE2/RAS 系统可能会减轻 SARS-CoV-2 和 SARS-CoV 引起的 ARDS 和急性肺损伤。维生素 D 被发现会影响 SARS-CoV-2 的靶标 ACE2；因此，我们提出维生素 D 可能通过调节 ACE2 来减轻 SARS-CoV-2 引起的 ARDS 和急性肺损伤。
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