College of Traditional Chinese medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Research Center for Infectious Diseases, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Cell Infect Microbiol. 2022 Jun 14;12:931061. doi: 10.3389/fcimb.2022.931061. eCollection 2022.
Novel coronavirus pneumonia (COVID-19) is spreading worldwide, causing great harm and stress to humans. Since patients with novel coronavirus (SARS-CoV-2) have a high probability of developing acute respiratory distress syndrome (ARDS) in severe cases, the pathways through which SARS-CoV-2 causes lung injury have become a major concern in the scientific field. In this paper, we investigate the relationship between SARS-CoV-2 and lung injury and explore the possible mechanisms of COVID-19 in ARDS from the perspectives of angiotensin-converting enzyme 2 protein, cytokine storm, activation of the immune response, triggering of Fas/FasL signaling pathway to promote apoptosis, JAK/STAT pathway, NF-κB pathway, type I interferon, vitamin D, and explore the possibility of prevention and treatment of COVID-19. To explore the possibility of SARS-CoV-2, and to provide new ideas to stop the development of ARDS in COVID-19 patients.
新型冠状病毒肺炎（COVID-19）在全球范围内传播，给人类带来了巨大的伤害和压力。由于新型冠状病毒（SARS-CoV-2）患者在严重情况下发生急性呼吸窘迫综合征（ARDS）的概率较高，因此 SARS-CoV-2 导致肺损伤的途径成为科学界关注的主要问题。本文从血管紧张素转换酶 2 蛋白、细胞因子风暴、免疫反应激活、Fas/FasL 信号通路触发促进细胞凋亡、JAK/STAT 通路、NF-κB 通路、I 型干扰素、维生素 D 等方面探讨 SARS-CoV-2 与肺损伤的关系，并探讨 COVID-19 中 ARDS 的可能机制，以期为 COVID-19 的防治提供新思路。探索 SARS-CoV-2 的可能性，并为阻止 COVID-19 患者 ARDS 的发展提供新的思路。
