Vuik Fanny E R, Nieuwenburg Stella A V, Moen Sarah, Schreuders Eline H, Oudkerk Pool Marinka D, Peterse Elisabeth F P, Spada Cristiano, Epstein Owen, Fernández-Urién Ignacio, Hofman Albert, Kuipers Ernst J, Spaander Manon C W
Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Department of Cardiology, Netherlands Heart Institute, Utrecht, the Netherlands.
Clin Gastroenterol Hepatol. 2022 Mar;20(3):692-700.e7. doi: 10.1016/j.cgh.2020.10.048. Epub 2020 Oct 31.
BACKGROUND & AIMS: The population prevalence of gastrointestinal (GI) disease is unclear and difficult to assess in an asymptomatic population. The aim of this study was to determine prevalence of GI lesions in a largely asymptomatic population undergoing colon capsule endoscopy (CCE).
Participants aged between 50-75 years were retrieved from the Rotterdam Study, a longitudinal epidemiological study, between 2017-2019. Participants received CCE with bowel preparation. Abnormalities defined as clinically relevant were Barrett segment >3cm, severe ulceration, polyp >10 mm or ≥3 polyps in small bowel (SB) or colon, and cancer.
Of 2800 invited subjects, 462 (16.5%) participants (mean age 66.8 years, female 53.5%) ingested the colon capsule. A total of 451 videos were analyzed, and in 94.7% the capsule reached the descending colon. At least 1 abnormal finding was seen in 448 (99.3%) participants. The prevalence of abnormalities per GI segment, and the most common type of abnormality, were as follows: Esophageal 14.8% (Barrett's esophagus <3 cm in 8.3%), gastric 27.9% (fundic gland polyps in 18.1%), SB abnormalities 33.9% (erosions in 23.8%), colon 93.3% (diverticula in 81.2%). A total of 54 participants (12%) had clinically relevant abnormalities, 3 (0.7%) in esophagus/stomach (reflux esophagitis grade D, Mallory Weiss lesion and severe gastritis), 5 (1.1%) in SB (polyps > 10 mm; n = 4, severe ulcer n = 1,) and 46 (10.2%) in colon (polyp > 10 mm or ≥3 polyps n = 46, colorectal cancer n = 1).
GI lesions are very common in a mostly asymptomatic Western population, and clinically relevant lesions were found in 12% at CCE. These findings provide a frame of reference for the prevalence rates of GI lesions in the general population.
胃肠道（GI）疾病在人群中的患病率尚不清楚，且难以在无症状人群中进行评估。本研究的目的是确定在接受结肠胶囊内镜检查（CCE）的大部分无症状人群中GI病变的患病率。
从鹿特丹研究（一项纵向流行病学研究）中选取2017年至2019年间年龄在50 - 75岁之间的参与者。参与者接受了肠道准备后的CCE检查。临床相关异常定义为Barrett段>3cm、严重溃疡、息肉>10mm或小肠（SB）或结肠中有≥3个息肉以及癌症。
在2800名受邀受试者中，462名（16.5%）参与者（平均年龄66.8岁，女性占53.5%）摄入了结肠胶囊。共分析了451份视频，94.7%的胶囊到达降结肠。448名（99.3%）参与者至少有1项异常发现。各GI段异常的患病率及最常见的异常类型如下：食管14.8%（Barrett食管<3cm占8.3%），胃27.9%（胃底腺息肉占18.1%），SB异常33.9%（糜烂占23.8%），结肠93.3%（憩室占81.2%）。共有54名参与者（12%）有临床相关异常，食管/胃有3名（0.7%）（反流性食管炎D级、Mallory Weiss病变和严重胃炎），SB有5名（1.1%）（息肉>10mm；4例，严重溃疡1例），结肠有46名（10.2%）（息肉>10mm或≥3个息肉46例，结直肠癌1例）。
GI病变在大多无症状的西方人群中非常常见，CCE检查中12%的人发现了临床相关病变。这些发现为一般人群中GI病变的患病率提供了一个参考框架。
