IRMB, INSERM, University of Montpellier, Montpellier, France.
IRMB, INSERM, University of Montpellier, Montpellier, France; Clinical department for osteoarticular diseases, University hospital of Montpellier, Montpellier, France.
Joint Bone Spine. 2021 Jan;88(1):105091. doi: 10.1016/j.jbspin.2020.105091. Epub 2020 Oct 31.
Rheumatoid arthritis (RA) is a prototypic autoimmune disease that primarily affects joints. Clinical studies and animal models evidenced that mononuclear phagocytes including monocytes and macrophages are crucial to RA pathogenesis, contributing to inflammation and destruction of cartilage and bone. The last decade of research has tremendously changed our view on the origin of tissue-resident macrophages. In light of the recent publications that reveal important phenotypic and functional heterogeneity among macrophages, it is of paramount importance to identify the synovial macrophage subsets that might amplify the inflammatory response or promote the restoration of tissue homeostasis. In this review, we highlight latest studies applying single-cell RNA sequencing that provide deeper insights in macrophage subsets and their putative functions within both human and mouse synovial joint tissue.
类风湿关节炎（RA）是一种典型的自身免疫性疾病，主要影响关节。临床研究和动物模型表明，单核吞噬细胞（包括单核细胞和巨噬细胞）对 RA 的发病机制至关重要，它们会导致软骨和骨的炎症和破坏。过去十年的研究极大地改变了我们对组织驻留巨噬细胞起源的看法。鉴于最近的出版物揭示了巨噬细胞之间存在重要的表型和功能异质性，因此确定可能放大炎症反应或促进组织内稳态恢复的滑膜巨噬细胞亚群至关重要。在这篇综述中，我们强调了应用单细胞 RNA 测序的最新研究，这些研究提供了对人类和小鼠滑膜关节组织中巨噬细胞亚群及其潜在功能的更深入了解。
