Wayne State University School of Medicine, 540 E. Canfield Avenue, Detroit, MI 48201, United States of America.
Department of Otolaryngology-Head & Neck Surgery, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI 48202, United States of America.
Am J Otolaryngol. 2021 Jan-Feb;42(1):102812. doi: 10.1016/j.amjoto.2020.102812. Epub 2020 Oct 24.
Malignant peripheral nerve sheath tumors (MPNSTs) are a rare and aggressive subtype of sarcomas defined by their neural origin. Head and neck manifestations are particularly uncommon. Challenges exist in diagnosis, management, and recurrence. Achieving local control, particularly in the head and neck region, is difficult. We present a patient with a rapidly enlarging MPNST on the right parietal calvarium shortly after resection of a right vagus nerve MPNST. Recommendation was made for excision and reconstruction with a local advancement flap followed by radiation therapy. Local control with good aesthetic outcome was achieved by applying recommended surgical and oncologic principles.
恶性外周神经鞘瘤（MPNST）是一种罕见且侵袭性的肉瘤亚型，其特征为神经起源。头颈部表现特别罕见。在诊断、治疗和复发方面存在挑战。在头颈部区域实现局部控制尤其困难。我们报告了 1 例患者，在切除右侧迷走神经 MPNST 后不久，右侧顶骨颅骨出现快速增大的 MPNST。建议采用局部推进皮瓣切除和重建，然后进行放射治疗。通过应用推荐的外科和肿瘤学原则，实现了局部控制和良好的美学效果。
