Hrek I, Rohozhyn A, Kushnir V, Kolesnikova O, Kochuieva M
1Kharkіv Medical Academy of Postgraduate Education; 3V.N. Karazin Kharkiv National University, Ukraine.
2SI «National Institute of Therapy named after L.T. Mala of NAMS of Ukraine», Ukraine.
Georgian Med News. 2020 Sep(306):81-87.
The study of the clinical and laboratory dynamics after an intensive phase of treatment in patients with firstly diagnosed pulmonary tuberculosis (FDTB) with alcohol consumption, and the development of a method for predicting the effectiveness of treatment. Examined 109 men with FDTB aged 20 to 50 years. Depending on the level of alcohol consumption, 3 groups of patients were formed. Patients of each group divided into two subgroups depending on the treatment regimen. The highest response to antioxidant therapy had indicators of phagocytic and enzymatic activity of neutrophils and endogenous intoxication. The dynamics of a decrease in all indicators of oxidative stress in groups 1 and 2 was higher in patients who additionally received antioxidants. The positive effects of group 3 was less. The models of prediction the positive dynamics level in the treatment of patients depending on the scheme therapy received have been developed. Predictors of treatment efficacy for patients with FDTB and alcohol intake with standard therapy are baseline alcohol consumption level, phagocytic index, and blood lymphocyte count. When prescribing antioxidants to a standard therapy regimen - initial level of alcohol consumption and phagocytic number. The degree of alcohol consumption is a common determinant of treatment effectiveness, regardless of treatment regimen.
对初诊为肺结核（FDTB）且有饮酒习惯的患者强化治疗阶段后的临床和实验室动态变化进行研究，并开发一种预测治疗效果的方法。研究了109名年龄在20至50岁之间的FDTB男性患者。根据饮酒量，将患者分为3组。每组患者根据治疗方案又分为两个亚组。对抗氧化治疗反应最高的是中性粒细胞的吞噬和酶活性指标以及内源性中毒指标。在第1组和第2组中，额外接受抗氧化剂治疗的患者氧化应激所有指标的下降动态更高。第3组的积极效果较小。已经建立了根据所接受的治疗方案预测患者治疗积极动态水平的模型。对于接受标准治疗的FDTB和饮酒患者，治疗效果的预测指标是基线饮酒量、吞噬指数和血液淋巴细胞计数。当在标准治疗方案中开具抗氧化剂时——初始饮酒量和吞噬细胞数量。饮酒程度是治疗效果的一个共同决定因素，无论治疗方案如何。
