Vyshnevska Iryna Ruslanivna, Kopytsya Mykola Pavlovych, Kutya Inna Mykolaevna, Protsenko Olena Sergiivna
Government Institution "L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine; V.N. Karazin National University, Kharkiv, Ukraine.
Government Institution "L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine.
Pol Merkur Lekarski. 2020 Oct 23;48(287):297-301.
One of the problems of modern cardiology in Ukraine and the world is acute coronary syndrome (ACS), which results in high mortality and invalidation of patients. Recently, much attention is drawn to the growth differentiation factor 15 (GDF-15). A lot of studies provided, in which the role of GDF-15 in cardiovascular pathology proved.
The aim of the study was to determine the predictive possibility of the GDF-15 marker in the stratification of the ACS complications risk within 5 years after the event.
70 patients with ACS were involved. The mean age was (61.8 +/- 1.3) years, the following diagnosis was established in the patients: 76 patients had acute myocardial infarction with Q (AMI with Q), 28 - acute myocardial infarction without Q (AMI without Q) and 36 patients were diagnosed unstable angina (UA). During the follow-up period the endpoint was reached by 28 patients.
A statistical relationship between the elevated level of GDF - 15 and the 5-year survival of these patients (χ2 = 4.75, p = 0.03) has been found. It was established that the level of the GDF-15 biomarker > 2350 pg/ml independently predicted the onset of adverse events with the sensitivity of 80% and the specificity of 60% (p = 0.006). To investigate the influence of the GDF-15 levels on mortality in the remote period, the Cox regression analysis was performed. It was revealed that the level of GDF-15 significantly predicted the onset of the primary endpoint within 5 years after ACS (p = 0.004).
The increased level of GDF-15, determined in the first 24 hours after development of ACS, is highly associated with the adverse outcome within 5 years after the event.
乌克兰和全球现代心脏病学面临的问题之一是急性冠状动脉综合征（ACS），它会导致患者高死亡率和残疾。最近，生长分化因子15（GDF - 15）备受关注。有许多研究证实了GDF - 15在心血管病理中的作用。
本研究的目的是确定GDF - 15标志物在ACS事件发生后5年内并发症风险分层中的预测可能性。
纳入70例ACS患者。平均年龄为（61.8±1.3）岁，患者确诊情况如下：76例为Q波急性心肌梗死（Q波AMI），28例为非Q波急性心肌梗死（非Q波AMI），36例诊断为不稳定型心绞痛（UA）。随访期间28例患者达到终点。
发现GDF - 15水平升高与这些患者的5年生存率之间存在统计学关系（χ2 = 4.75，p = 0.03）。已确定GDF - 15生物标志物水平> 2350 pg/ml可独立预测不良事件的发生，敏感性为80%，特异性为60%（p = 0.006）。为研究GDF - 15水平对远期死亡率的影响，进行了Cox回归分析。结果显示，GDF - 15水平显著预测了ACS后5年内主要终点的发生（p = 0.004）。
在ACS发生后的最初24小时内测定的GDF - 15水平升高与事件发生后5年内的不良结局高度相关。
