Romańczyk Monika, Surma STANISłAW, Łabuzek Krzysztof
Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland.
Specialist Medical Practice in Jaworzno, Poland.
Pol Merkur Lekarski. 2020 Oct 23;48(287):370-374.
Natriuretic peptides are peptide hormones which are involved in the regulation of blood pressure, water-mineral balance and multiple metabolic processes. The beginning of research on this group of hormones starts in 1981, when the deBold and collaborators discovered ANP. Eight natriuretic peptides have been described so far: ANP, BNP, CNP, DNP, urodilatin, uroguanylin, osteocrin, musculin and three receptors: NPR-A, NPR-B and NPR-C thanks to which these hormones accomplish their physiological functions. Determination of natriuretic peptide concentration in plasma is used in the diagnosis and treatment of heart failure and pulmonary embolism. Research results indicate that the determination of natriuretic peptides concentration in plasma may also be important in the acute coronary syndromes, subclinical complications of hypertension and atrial fibrillation. The concentration of natriuretic peptides is changing in many diseases. The beneficial effects of natriuretic peptides have led to the production of drugs that are their synthetic derivatives. These drugs are mainly used among patients with heart failure. Research is currently underway on the efficacy and safety of other synthetic natriuretic peptides.
利钠肽是一类肽激素，参与血压调节、水盐平衡及多种代谢过程。对这组激素的研究始于1981年，当时德博尔德及其合作者发现了心房钠尿肽。迄今为止，已描述了八种利钠肽：心房钠尿肽、脑钠肽、C型钠尿肽、D型钠尿肽、尿舒张素、尿鸟苷素、骨分泌素、肌肉分泌素，以及三种受体：A型利钠肽受体、B型利钠肽受体和C型利钠肽受体，这些激素通过它们实现其生理功能。血浆中利钠肽浓度的测定用于心力衰竭和肺栓塞的诊断与治疗。研究结果表明，血浆中利钠肽浓度的测定在急性冠脉综合征、高血压亚临床并发症和心房颤动中也可能具有重要意义。利钠肽的浓度在许多疾病中都会发生变化。利钠肽的有益作用促使人们生产出其合成衍生物药物。这些药物主要用于心力衰竭患者。目前正在对其他合成利钠肽的疗效和安全性进行研究。
