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一名患有慢性轻度贫血和原发性铁过载疾病的日本女性。

A Japanese female with chronic mild anemia and primary iron overloading disease.

作者信息

Hattori Yukinori, Kato Hiroyuki, Kato Ayako, Tatsumi Yasuaki, Kato Koichi, Hayashi Hisao

机构信息

Department of Pathology, Japan Community Health care Organization, Chukyo Hospital, Nagoya, Japan.

Department of Cardiology, Japan Community Health care Organization, Chukyo Hospital, Nagoya, Japan.

出版信息

Nagoya J Med Sci. 2020 Aug;82(3):579-583. doi: 10.18999/nagjms.82.3.579.

DOI:10.18999/nagjms.82.3.579
PMID:33132441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7548253/
Abstract

A 65-year-old woman died of congestive heart failure and diabetes mellitus. She had a history of mild anemia since adolescence, but received neither iron supplementation nor transfusion. The cirrhotic liver obtained at autopsy contained a large amount of iron. The heart and pancreas also had excess iron. Her iron overload may be due to excess iron absorption in the gut because of the absence of an iatrogenic background such as transfusion or iron supplementation.

摘要

一名65岁女性死于充血性心力衰竭和糖尿病。她自青少年时期就有轻度贫血病史,但未接受过铁剂补充或输血治疗。尸检获得的肝硬化肝脏含有大量铁。心脏和胰腺也有铁过量的情况。由于不存在输血或铁剂补充等医源性背景,她的铁过载可能是由于肠道铁吸收过多所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b567/7548253/2b3a25fa7591/2186-3326-82-0579-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b567/7548253/2b3a25fa7591/2186-3326-82-0579-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b567/7548253/2b3a25fa7591/2186-3326-82-0579-g001.jpg

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Int J Hematol. 2018 Jan;107(1):31-43. doi: 10.1007/s12185-017-2365-3. Epub 2017 Nov 13.
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Ineffective erythropoiesis and regulation of iron status in iron loading anaemias.铁过载性贫血中无效的红细胞生成和铁状态的调节。
Br J Haematol. 2016 Feb;172(4):512-23. doi: 10.1111/bjh.13820. Epub 2015 Oct 22.
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Deferasirox Decreases Liver Iron Concentration in Iron-Overloaded Patients with Myelodysplastic Syndromes, Aplastic Anemia and Other Rare Anemias.
地拉罗司可降低骨髓增生异常综合征、再生障碍性贫血及其他罕见贫血的铁过载患者的肝脏铁浓度。
Acta Haematol. 2015;134(4):233-42. doi: 10.1159/000381893.
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Clinicopathological study of Japanese patients with genetic iron overload syndromes.日本遗传性铁过载综合征患者的临床病理研究。
Pathol Int. 2012 Sep;62(9):612-8. doi: 10.1111/j.1440-1827.2012.02848.x.
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Improvement of iron-mediated oxidative DNA damage in patients with transfusion-dependent myelodysplastic syndrome by treatment with deferasirox.地拉罗司治疗输血依赖型骨髓增生异常综合征患者铁介导的氧化 DNA 损伤的改善作用。
Free Radic Biol Med. 2012 Aug 15;53(4):643-8. doi: 10.1016/j.freeradbiomed.2012.06.006. Epub 2012 Jun 15.
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Biochim Biophys Acta. 2012 Sep;1823(9):1434-43. doi: 10.1016/j.bbamcr.2012.01.014. Epub 2012 Jan 26.
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