Sun Liguang, Jin Chun-Hui, Tan Shulian, Liu Wentao, Yang Yong-Guang
Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Jilin University, Changchun, China.
Front Immunol. 2020 Oct 8;11:591669. doi: 10.3389/fimmu.2020.591669. eCollection 2020.
Mouse models are the most commonly used system for biomedical research, in which immune-related diseases and therapies can be investigated in syngeneic and immunologically intact hosts. However, because there are significant differences between rodent and human, most findings from conventional mouse models cannot be applied to humans. The humanized mouse with a functional human immune system, also referred to as human immune system (HIS) mouse, is the only model available to date for studies in real-time of human immune function under physiological and pathological conditions. HIS mice with human tumor xenografts are considered an emerging and promising model for modeling human cancer immunotherapy. In this review, we briefly discuss the protocols to construct HIS mice and elaborate their pros and cons. Particular attention is given to HIS mouse models with human tumor that is autologous or genetically identical to the human immune system, which are discussed with examples of their usefulness in modeling human cancer immunotherapies.
小鼠模型是生物医学研究中最常用的系统，在该系统中，可以在同基因且免疫功能完整的宿主中研究免疫相关疾病和疗法。然而，由于啮齿动物和人类之间存在显著差异，传统小鼠模型的大多数研究结果无法应用于人类。具有功能性人类免疫系统的人源化小鼠，也称为人类免疫系统（HIS）小鼠，是迄今为止唯一可用于在生理和病理条件下实时研究人类免疫功能的模型。带有人类肿瘤异种移植物的HIS小鼠被认为是一种新兴且有前景的人类癌症免疫治疗建模模型。在这篇综述中，我们简要讨论构建HIS小鼠的方案，并阐述其优缺点。特别关注具有与人类免疫系统自体或基因相同的人类肿瘤的HIS小鼠模型，并举例说明它们在人类癌症免疫治疗建模中的用途。
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