Tiscornia O M, Dreiling D A
Gastroenterology Section, Clinicas Hospital, University of Buenos Aires.
Pancreas. 1987;2(5):604-12.
In the rat, basal pancreatic secretion is generated and modulated by positive and negative duodeno-pancreatic reflexes. The former activates secretion, the latter acts as a "brake". Impairment of this brake plays a crucial role in the pathogenesis of alcoholic pancreatitis by causing elevation of pancreatic cholinergic tone and inducing increased pancreon ecbolic response to CCK-PZ stimulation. Both factors lead to pancreatic damage by supranormal stimulation of the pancreon.
在大鼠中，胰腺基础分泌由十二指肠-胰腺的正、负反射产生并调节。前者激活分泌，后者起“刹车”作用。这种“刹车”功能受损在酒精性胰腺炎的发病机制中起关键作用，它会导致胰腺胆碱能张力升高，并诱导胰腺对胆囊收缩素-胰酶泌素（CCK-PZ）刺激的分泌反应增强。这两个因素都会通过对胰腺的超常刺激导致胰腺损伤。
