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单核细胞分化中间步骤的模型：以c-myc、c-fms和铁蛋白作为标志物

Model for intermediate steps in monocytic differentiation: c-myc, c-fms, and ferritin as markers.

作者信息

Cayre Y, Raynal M C, Darzynkiewicz Z, Dorner M H

机构信息

Program in Immunology, Memorial Sloan-Kettering Cancer Center, Cornell University Graduate School of Medical Sciences, New York, NY 10021.

出版信息

Proc Natl Acad Sci U S A. 1987 Nov;84(21):7619-23. doi: 10.1073/pnas.84.21.7619.

DOI:10.1073/pnas.84.21.7619
PMID:3313399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC299351/
Abstract

A mature hematopoietic cell represents the end product of a stepwise differentiation process. As a model system for studying differentiation, the human promyelocytic leukemia cell line HL-60 undergoes terminal monocytic/macrophagic differentiation following exposure to either phorbol 12-myristate 13-acetate or 1,25-dihydroxyvitamin D3. We have derived and analyzed a variant HL-60 cell line, 1F10, that permits the study of several intermediate steps in the myeloid differentiation process. These intermediate steps are documented by cell cycle data and phenotype analysis as well as markers such as c-myc, c-fms, and both subunits of ferritin.

摘要

成熟的造血细胞是逐步分化过程的最终产物。作为研究分化的模型系统，人早幼粒细胞白血病细胞系HL-60在暴露于佛波酯12-肉豆蔻酸酯13-乙酸酯或1,25-二羟基维生素D3后会经历终末单核细胞/巨噬细胞分化。我们已经衍生并分析了一种变体HL-60细胞系1F10，它可用于研究髓系分化过程中的几个中间步骤。这些中间步骤通过细胞周期数据、表型分析以及诸如c-myc、c-fms和铁蛋白的两个亚基等标志物得以记录。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/c8bf4bc9b0fe/pnas00336-0272-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/4e3dc78c43f9/pnas00336-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/2be85b9a9b81/pnas00336-0272-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/0bc8ab9fe118/pnas00336-0272-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/77b9e6aca066/pnas00336-0272-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/23b764b9a19f/pnas00336-0272-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/c8bf4bc9b0fe/pnas00336-0272-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/4e3dc78c43f9/pnas00336-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/2be85b9a9b81/pnas00336-0272-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/0bc8ab9fe118/pnas00336-0272-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/77b9e6aca066/pnas00336-0272-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/23b764b9a19f/pnas00336-0272-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/299351/c8bf4bc9b0fe/pnas00336-0272-e.jpg

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本文引用的文献

1
Human neutrophil Fc gamma receptor distribution and structure.人类中性粒细胞Fcγ受体的分布与结构。
Proc Natl Acad Sci U S A. 1982 May;79(10):3275-9. doi: 10.1073/pnas.79.10.3275.
2
Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation.化学转化后，c-myc的细胞周期控制丧失，但c-ras的表达未受影响。
Cell. 1984 Feb;36(2):241-7. doi: 10.1016/0092-8674(84)90217-4.
3
Cell cycle-specific effects of tumor necrosis factor.肿瘤坏死因子的细胞周期特异性效应
Cancer Chemother Pharmacol. 1990;27(3):171-7. doi: 10.1007/BF00685709.
4
Wegener autoantigen and myeloblastin are encoded by a single mRNA.韦格纳自身抗原和成髓细胞素由单一信使核糖核酸编码。
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9253-6. doi: 10.1073/pnas.88.20.9253.
5
Simultaneous detection of ferritin and HIV-1 in reactive microglia.在反应性小胶质细胞中同时检测铁蛋白和HIV-1。
Acta Neuropathol. 1992;84(3):297-306. doi: 10.1007/BF00227823.
Cancer Res. 1984 Jan;44(1):83-90.
4
Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite.一种维生素D代谢物对HL-60白血病细胞中myc基因表达的调控
Nature. 1983;306(5942):492-4. doi: 10.1038/306492a0.
5
1,25-dihydroxyvitamin D3 inhibits proliferation of human promyelocytic leukaemia (HL60) cells and induces monocyte-macrophage differentiation in HL60 and normal human bone marrow cells.1,25-二羟基维生素D3抑制人早幼粒细胞白血病（HL60）细胞的增殖，并诱导HL60细胞和正常人骨髓细胞向单核细胞-巨噬细胞分化。
Leuk Res. 1983;7(1):51-5. doi: 10.1016/0145-2126(83)90057-7.
6
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.淋巴细胞有丝分裂原和血小板衍生生长因子对c-myc基因的细胞特异性调控。
Cell. 1983 Dec;35(3 Pt 2):603-10. doi: 10.1016/0092-8674(83)90092-2.
7
Relative subunit composition of the ferritin synthesized by selected human lymphomyeloid cell populations.特定人类淋巴髓样细胞群体合成的铁蛋白的相对亚基组成。
Exp Hematol. 1983 Oct;11(9):866-72.
8
Activation of a translocated c-myc gene: role of structural alterations in the upstream region.易位的c-myc基因的激活：上游区域结构改变的作用
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6798-802. doi: 10.1073/pnas.81.21.6798.
9
Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases.猫逆转录病毒致癌基因v-fms的核苷酸序列与编码酪氨酸特异性蛋白激酶的致癌基因显示出意外的同源性。
Proc Natl Acad Sci U S A. 1984 Jan;81(1):85-9. doi: 10.1073/pnas.81.1.85.
10
Double minute chromatin bodies and other chromosome alterations in human myeloid HL-60 leukemia cells susceptible or resistant to induction of differentiation by phorbol-12-myristate-13-acetate.
Cancer Res. 1983 Dec;43(12 Pt 1):5873-8.