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一名因前列腺癌转移导致肝内出血继发梗阻性黄疸的患者。

A patient with obstructive jaundice secondary to intrahepatic bleeding caused by prostate cancer metastasis.

作者信息

Adawi Essa A

机构信息

Surgical Department, Faculty of Medicine, Jazan University, Saudi Arabia.

出版信息

Urol Case Rep. 2020 Oct 22;34:101443. doi: 10.1016/j.eucr.2020.101443. eCollection 2021 Jan.

DOI:10.1016/j.eucr.2020.101443
PMID:33134084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7588697/
Abstract

A metastatic disease causes jaundice is not uncommon and usually related to direct tumor invasion to the biliary tree or massive intrahepatic metastasis. Cholestasis secondary to non-traumatic intrahepatic bleeding caused by metastasis from prostate cancer is never been reported in the literature. We present the first case of a-71-years-old patient developed Cholestasis due to spontaneous intrahepatic bleeding caused by metastasis from prostate cancer that was successfully treated conservatively. Prostatic cancer causes liver metastasis carries worse prognosis and compression of the intrahepatic biliary ducts can have long term unsatisfactory outcomes.

摘要

转移性疾病导致黄疸并不罕见,通常与肿瘤直接侵犯胆管树或大量肝内转移有关。文献中从未报道过前列腺癌转移引起的非创伤性肝内出血继发胆汁淤积的情况。我们报告了首例71岁患者因前列腺癌转移导致自发性肝内出血而出现胆汁淤积,经保守治疗成功治愈的病例。前列腺癌引起肝转移预后较差,肝内胆管受压可能导致长期不理想的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae67/7588697/b6ad87e47f30/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae67/7588697/b6ad87e47f30/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae67/7588697/b6ad87e47f30/gr1.jpg

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本文引用的文献

1
Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome.转移性前列腺癌中的可逆性肝内胆汁淤积:一种罕见的副肿瘤综合征。
Mol Clin Oncol. 2018 Apr;8(4):609-612. doi: 10.3892/mco.2018.1564. Epub 2018 Feb 2.
2
A patient with obstructive jaundice due to bleeding in the common bile duct after ultrasound-guided liver biopsy.一名在超声引导下肝活检后因胆总管出血导致梗阻性黄疸的患者。
Tokai J Exp Clin Med. 2010 Sep 20;35(3):107-11.
3
Paraneoplastic hepatic dysfunction in metastatic prostate cancer: the role of cytokine dysregulation.
J Clin Oncol. 2011 Jan 10;29(2):e21-3. doi: 10.1200/JCO.2010.30.6522. Epub 2010 Oct 12.
4
Cholestatic jaundice as a paraneoplastic manifestation of prostate adenocarcinoma.胆汁淤积性黄疸作为前列腺腺癌的副肿瘤表现。
Clin Gastroenterol Hepatol. 2003 Nov;1(6):480-3. doi: 10.1016/s1542-3565(03)00227-1.
5
Metastatic prostate cancer (with prostate-specific antigen of 9996) presenting as obstructive jaundice.
Am J Med Sci. 2000 Feb;319(2):118-22. doi: 10.1097/00000441-200002000-00009.