Venkatesan Dhivya, Iyer Mahalaxmi, Narayanasamy Arul, Siva Kamalakannan, Vellingiri Balachandar
Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.
Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.
eNeurologicalSci. 2020 Sep 10;21:100270. doi: 10.1016/j.ensci.2020.100270. eCollection 2020 Dec.
Parkinson's disease (PD) is a complex multi-factorial neurodegenerative disorder where various altered metabolic pathways contribute to the progression of the disease. Tryptophan (TRP) is a major precursor in kynurenine pathway (KP) and it has been discussed in various studies that the metabolites quinolinic acid (QUIN) causes neurotoxicity and kynurenic acid (KYNA) acts as neuroprotectant respectively. More studies are also focused on the effects of other KP metabolites and its enzymes as it has an association with ageing and PD pathogenesis. Until now, very few studies have targeted the role of genetic mutations in abnormal KP metabolism in adverse conditions of PD. Therefore, the present review gives an updated research studies on KP in connection with PD. Moreover, the review emphasizes on the urge for the development of biomarkers and also this would be an initiative in generating an alternative therapeutic approach for PD.
帕金森病(PD)是一种复杂的多因素神经退行性疾病,其中各种代谢途径的改变促成了该疾病的进展。色氨酸(TRP)是犬尿氨酸途径(KP)中的主要前体,并且在各种研究中已经讨论过,代谢物喹啉酸(QUIN)会导致神经毒性,而犬尿烯酸(KYNA)分别起到神经保护剂的作用。更多研究也集中在其他KP代谢物及其酶的作用上,因为它与衰老和PD发病机制有关。到目前为止,很少有研究针对PD不利条件下异常KP代谢中基因突变的作用。因此,本综述给出了与PD相关的KP的最新研究。此外,该综述强调了开发生物标志物的迫切性,这也将是为PD生成替代治疗方法的一项举措。