Shyamsivappan Selvaraj, Saravanan Arjunan, Vandana Nandakumar, Suresh Thangaraj, Suresh Shanmugam, Nandhakumar Raju, Mohan Palathurai Subramaniam
School of Chemical Sciences, Bharathiar University, Coimbatore, Tamil Nadu 641046, India.
DRDO-BU CLS, Bharathiar University, Coimbatore, Tamil Nadu 641046, India.
ACS Omega. 2020 Oct 12;5(42):27245-27253. doi: 10.1021/acsomega.0c03445. eCollection 2020 Oct 27.
New quinoline-based thiazole derivatives and were synthesized and characterized by various spectroscopic and single-crystal X-ray crystallographic studies. The metal-sensing properties of the probes were further examined by absorption and fluorescence spectrometry. The fluorescence intensity of and was remarkably quenched during the addition of Fe, Fe, and Cu ions in THF/HO (1:1) at pH = 7.4 in HEPES buffer, while the addition of other metal ions did not affect the fluorescence intensity of the ligands. The detection ability of the probes and was further investigated by titration with various equivalents of metal ions, optimized pH ranges for detection, and reversibility with NaEDTA for biological applications.
合成了新型喹啉基噻唑衍生物，并通过各种光谱和单晶X射线晶体学研究对其进行了表征。通过吸收光谱和荧光光谱进一步研究了探针的金属传感特性。在pH = 7.4的HEPES缓冲液中，于THF/H₂O（1:1）中加入Fe³⁺、Fe²⁺和Cu²⁺离子时，[具体化合物名称1]和[具体化合物名称2]的荧光强度显著猝灭，而加入其他金属离子则不影响配体的荧光强度。通过用各种当量的金属离子进行滴定、优化检测的pH范围以及用于生物应用时与NaEDTA的可逆性，进一步研究了探针[具体化合物名称1]和[具体化合物名称2]的检测能力。
