Chou Ping, Wang Guan-Hsun, Hsueh Shu-Wei, Yang Ya-Chin, Kuo Chung-Chin
Department of Physiology, National Taiwan University College of Medicine, 1 Jen-Ai Road, 1st Section, Taipei 100, Taiwan.
Department of Biomedical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan.
iScience. 2020 Oct 9;23(11):101666. doi: 10.1016/j.isci.2020.101666. eCollection 2020 Nov 20.
Epileptic seizures constitute a common neurological disease primarily diagnosed by characteristic rhythms or waves in the local field potentials (LFPs) of cerebral cortices or electroencephalograms. With a basolateral amygdala (BLA) kindling model, we found that the dominant frequency of BLA oscillations is in the delta range (1-5 Hz) in both normal and seizure conditions. Multi-unit discharges are increased with higher seizure staging but remain phase-locked to the delta waves in LFPs. Also, the change in synchrony precedes and outlasts the changes in discharging units as well as behavioral seizures. One short train of stimuli readily drives the pyramidal-inhibitory neuronal networks in BLA slices into prolonged reverberating activities, where the burst and interburst intervals may concurrently set a "natural wavelength" for delta frequencies. Seizures thus could be viewed as erroneous temporospatial continuums to normal oscillations in a system with a built-in synchronizing and resonating nature for information relay.
癫痫发作是一种常见的神经系统疾病，主要通过大脑皮层局部场电位（LFP）或脑电图中的特征性节律或波来诊断。利用基底外侧杏仁核（BLA）点燃模型，我们发现，在正常和癫痫发作条件下，BLA振荡的主导频率均处于δ波范围（1-5赫兹）。随着癫痫发作分期的升高，多单位放电增加，但在LFP中仍与δ波锁相。此外，同步性的变化先于放电单位的变化和行为性癫痫发作，且持续时间更长。一短串刺激很容易驱动BLA切片中的锥体-抑制性神经元网络进入长时间的回响活动，其中爆发和爆发间期可能同时为δ频率设定一个“自然波长”。因此，癫痫发作可被视为一个具有信息中继的内置同步和共振性质的系统中，与正常振荡的错误时空连续体。
