Bedel Cihan, Korkut Mustafa, Aksoy Fatih, Kuş Görkem
Arch Acad Emerg Med. 2020 Sep 15;8(1):e73. eCollection 2020.
Immature granulocytes (IG) in peripheral blood indicate increased bone marrow activation and inflammation, and SYNTAX score (SS) is an anatomical scoring system based on coronary angiogram. This study, aimed to evaluate the relationship between IG and SS, as a new inflammatory marker in patients with acute coronary syndrome (ACS).
Patients aged >18 years who were diagnosed with ACS in the emergency department were included in this study, which was planned as a cross-sectional study. Patients were divided into two groups of patients with high and low SSs according to coronary angiography results. Demographic and laboratory parameters were compared between the groups.
Our study consisted of 78 patients diagnosed with ACS, who met the inclusion criteria. The average age of the study group was 59 years, and 67.9% of the patients were male. 21 patients (26.9%) had high SSs and 57 patients (73.1%) had low SSs. Mean IG% was significantly higher in high SS group compared to low SS group (0.71±0.25 vs 0.44±0.21 mg/dl, p<0.001). IG% can present a high SS with 76.2% sensitivity and 75.4% specificity at a cut-off value of 0.7.
IG was significantly higher in ACS patients with high SSs. It seems that IG can be used as a parameter, which is quickly accessible and cheap, in order to predict high SS in ACS patients in daily clinical practice.
外周血中的未成熟粒细胞（IG）表明骨髓激活和炎症增加，而SYNTAX评分（SS）是一种基于冠状动脉造影的解剖学评分系统。本研究旨在评估IG与SS之间的关系，IG作为急性冠状动脉综合征（ACS）患者的一种新的炎症标志物。
本研究纳入了在急诊科被诊断为ACS且年龄大于18岁的患者，该研究计划为横断面研究。根据冠状动脉造影结果将患者分为SS高分组和低分组。比较两组患者的人口统计学和实验室参数。
我们的研究包括78例符合纳入标准的诊断为ACS的患者。研究组的平均年龄为59岁，67.9%的患者为男性。21例患者（26.9%）SS高，57例患者（73.1%）SS低。高SS组的平均IG%显著高于低SS组（0.71±0.25 vs 0.44±0.21 mg/dl，p<0.001）。在截断值为0.7时，IG%对高SS的敏感性为76.2%，特异性为75.4%。
高SS的ACS患者中IG显著更高。在日常临床实践中，IG似乎可以作为一个易于获取且廉价的参数，用于预测ACS患者的高SS。
