在埃及，环丙沙星与甲氧苄啶-磺胺甲恶唑针对引起旅行者腹泻的弯曲杆菌属、志贺菌属和产肠毒素大肠杆菌的体外活性比较。

In vitro activity of ciprofloxacin compared to trimethoprim-sulfamethoxazole against Campylobacter spp., Shigella spp. and Enterotoxigenic Escherichia coli causing travellers' diarrhea in Egypt.

作者信息

Mikhail I A, Bourgeois A L, Hyams K C, Podgore J K, Lissner C R, Walz S

机构信息

Department of Bacteriology, U.S. Naval Medical Research Unit No. 3, Cairo, Egypt.

出版信息

Scand J Infect Dis. 1987;19(4):479-81. doi: 10.3109/00365548709021682.

DOI:10.3109/00365548709021682

PMID:3313681

Abstract

The in vitro activity of ciprofloxacin against bacterial enteropathogens isolated from cases of travellers' diarrhea in Egypt was compared to trimethoprim (TMP) and trimethoprim-sulfamethoxazole (SXT). No resistance to ciprofloxacin was noted for any of the Campylobacter jejuni/coli, Shigella spp., and enterotoxigenic Escherichia coli strains examined. However, resistance to TMP and SXT was noted among these same strains. Because of its broad spectrum and lack of resistance, ciprofloxacin is potentially a useful drug for the treatment of diarrhea caused by bacterial enteropathogens encountered in this region of the world.

摘要

将环丙沙星对从埃及旅行者腹泻病例中分离出的细菌性肠道病原体的体外活性与甲氧苄啶（TMP）和甲氧苄啶-磺胺甲恶唑（SXT）进行了比较。在所检测的空肠弯曲菌/结肠弯曲菌、志贺氏菌属和产肠毒素大肠杆菌菌株中，未发现对环丙沙星耐药。然而，在这些相同菌株中发现了对TMP和SXT耐药。由于环丙沙星具有广谱性且无耐药性，它可能是治疗世界该地区细菌性肠道病原体引起的腹泻的一种有用药物。