糖尿病肾病中的脂质沉积和代谢炎症。
Lipid deposition and metaflammation in diabetic kidney disease.
机构信息
Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA; Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, Miami, FL, USA; Department of Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA.
Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA; Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, Miami, FL, USA.
出版信息
Curr Opin Pharmacol. 2020 Dec;55:60-72. doi: 10.1016/j.coph.2020.09.004. Epub 2020 Nov 1.
Abstract
A critical link between metabolic disorders and a form of low-grade systemic and chronic inflammation has been recently established and named 'Metaflammation'. Metaflammation has been recognized as a key mediator of both microvascular and macrovascular complications of diabetes and as a significant contributor to the development of diabetic kidney disease (DKD). The goal of this review is to summarize the contribution of diabetes-induced inflammation and the related signaling pathways to diabetic complications, with a particular focus on how innate immunity and lipid metabolism influence each other.
摘要
代谢紊乱与一种低度系统性和慢性炎症之间的关键联系最近已被确定，并被命名为“代谢炎症”。代谢炎症已被认为是糖尿病微血管和大血管并发症的关键介质，也是糖尿病肾病（DKD）发展的重要因素。本篇综述的目的是总结糖尿病引起的炎症及其相关信号通路对糖尿病并发症的贡献，特别关注固有免疫和脂质代谢如何相互影响。
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