Patrusheva I F, Iurenev A P
Ter Arkh. 1987;59(7):101-3.
The authors provided an analysis of the results of 3-year follow-up and therapy of 32 patients with hypertension developing with blood renin low activity. A prolonged, statistically significant decrease in the AP level with the improvement of the patients' subjective status was noted in continuous adequate hypotensive therapy. The most severe clinical course was observed in the group of patients with unresected adrenal adenoma. During treatment of patients with primary aldosteronism with spironolactone one should pay attention to the presence of some concomitant diseases (mastopathy, myoma of the uterus) because this drug may turn their course unfavorably, thus making the treatment of patients with adrenal pathology difficult.
作者对32例肾素活性低的高血压患者进行了为期3年的随访及治疗结果分析。在持续充分的降压治疗中，观察到动脉血压水平持续且具有统计学意义的下降，同时患者的主观状态有所改善。未切除肾上腺腺瘤的患者组临床病程最为严重。在用螺内酯治疗原发性醛固酮增多症患者时，应注意一些伴随疾病（乳腺病、子宫肌瘤）的存在，因为这种药物可能使这些疾病的病程恶化，从而使肾上腺疾病患者的治疗变得困难。
